LCST polymers: Thermoresponsive nanostructured assemblies towards bioapplications

Thermoresponsive polymers constitute an important class of materials for biomedical application due to their thermally reversible coil-to-globule transition which can be exploited in a multitude of biomedical applications spanning from triggered drug delivery systems in the form of bulk hydrogels an...

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Bibliographic Details
Published in:Polymer (Guilford) Vol. 211; p. 123146
Main Authors: Pasparakis, George, Tsitsilianis, Constantinos
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 21.12.2020
Elsevier BV
Subjects:
Actuators
Assemblies
Assembly
Bioapplication
Biomedical materials
Cell culture
Coils
Drug delivery
Drug delivery systems
Hydrogels
LCST
Micelles
Microcapsules
Microgels
Nanoparticles
Physicochemical properties
Polyisopropyl acrylamide
Polymers
Smart sensors
Thermoresponsive polymer
LCST
Thermoresponsive polymer
Assembly
Bioapplication
ISSN:0032-3861, 1873-2291
Online Access:Get full text
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Summary:Thermoresponsive polymers constitute an important class of materials for biomedical application due to their thermally reversible coil-to-globule transition which can be exploited in a multitude of biomedical applications spanning from triggered drug delivery systems in the form of bulk hydrogels and nanoparticles, “smart” cell culture setups, sensors and actuators, and separation technologies. In this perspective article we present the basic physicochemical properties of poly (N-isopropylacrylamide) (PNIPAM), which is the most widely studied thermoresponsive polymer with a lower critical solution temperature. We describe the basic thermodynamic and physicochemical parameters that affect the LCST and present selective applications that utilize thermoresponsive polymers in the form of nano-assemblies including micelles, polymersomes, microcapsules and microgels, as well as injectable hydrogels for biomedical applications. [Display omitted] •Thermoresponsive polymers and their key properties in aqueous media are presented.•The lower critical solution temperature and the factors affecting it in aqueous media are described.•T-responsive polymers in the form of micelles, polymersomes, microcapsules, and microgels are discussed.•Injectable thermoresponsive hydrogels with shear thinning properties are introduced for bioapplications.
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ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2020.123146