Superwettable nanodendritic gold substrates for direct miRNA SERS detection

By combining a superwettable interface with a nanodendritic gold structure, we have fabricated a superwettable nanodendritic gold substrate for direct SERS detection of multiple concentrations of miRNAs. The nanodendritic gold substrate provides numerous hotspots for Raman signal enhancement, and th...

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Bibliographic Details
Published in:Nanoscale Vol. 10; no. 45; p. 20990
Main Authors: Song, Yongchao, Xu, Tailin, Xu, Li-Ping, Zhang, Xueji
Format: Journal Article
Language:English
Published: England 07.12.2018
Subjects:
Dendrimers - chemistry
DNA Probes - metabolism
Gold - chemistry
Hydrophobic and Hydrophilic Interactions
MicroRNAs - analysis
MicroRNAs - metabolism
Nanostructures - chemistry
Rhodamines - chemistry
Spectrum Analysis, Raman
Surface Properties
ISSN:2040-3372, 2040-3372
Online Access:Get more information
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Summary:By combining a superwettable interface with a nanodendritic gold structure, we have fabricated a superwettable nanodendritic gold substrate for direct SERS detection of multiple concentrations of miRNAs. The nanodendritic gold substrate provides numerous hotspots for Raman signal enhancement, and the superwettable interface ensures the immobilization of droplets in superhydrophilic microwells, which hold great potentials for applications in disease diagnostics.
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ISSN:2040-3372
2040-3372
DOI:10.1039/c8nr07348a