Metabolic syndrome and cognitive decline in French elders: the Three-City Study

To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions. Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in t...

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Published in:Neurology Vol. 76; no. 6; p. 518
Main Authors: Raffaitin, C, Féart, C, Le Goff, M, Amieva, H, Helmer, C, Akbaraly, T N, Tzourio, C, Gin, H, Barberger-Gateau, P
Format: Journal Article
Language:English
Published: United States 08.02.2011
Subjects:
Aged
Cognition Disorders - epidemiology
Cognition Disorders - etiology
Cognition Disorders - psychology
Cohort Studies
Female
Follow-Up Studies
France - epidemiology
Humans
Longitudinal Studies
Male
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - psychology
Neuropsychological Tests
Prospective Studies
Risk Factors
ISSN:1526-632X, 1526-632X
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Abstract To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions. Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders. MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST. MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
AbstractList To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions.OBJECTIVETo examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions.Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders.METHODSParticipants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders.MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST.RESULTSMetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST.MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.CONCLUSIONSMetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions. Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders. MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST. MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
Author Barberger-Gateau, P
Amieva, H
Tzourio, C
Le Goff, M
Gin, H
Helmer, C
Akbaraly, T N
Raffaitin, C
Féart, C
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  surname: Raffaitin
  fullname: Raffaitin, C
  email: christelle.raffaitin@isped.u-bordeaux2.fr
  organization: Diabetology–Nutrition Unit, University Hospital of Bordeaux, Pessac, France. christelle.raffaitin@isped.u-bordeaux2.fr
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21288982$$D View this record in MEDLINE/PubMed
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Snippet To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions....
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SubjectTerms Aged
Cognition Disorders - epidemiology
Cognition Disorders - etiology
Cognition Disorders - psychology
Cohort Studies
Female
Follow-Up Studies
France - epidemiology
Humans
Longitudinal Studies
Male
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - psychology
Neuropsychological Tests
Prospective Studies
Risk Factors
Title Metabolic syndrome and cognitive decline in French elders: the Three-City Study
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