Metabolic syndrome and cognitive decline in French elders: the Three-City Study

To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions. Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neurology Ročník 76; číslo 6; s. 518
Hlavní autoři: Raffaitin, C, Féart, C, Le Goff, M, Amieva, H, Helmer, C, Akbaraly, T N, Tzourio, C, Gin, H, Barberger-Gateau, P
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 08.02.2011
Témata:
Aged
Cognition Disorders - epidemiology
Cognition Disorders - etiology
Cognition Disorders - psychology
Cohort Studies
Female
Follow-Up Studies
France - epidemiology
Humans
Longitudinal Studies
Male
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - psychology
Neuropsychological Tests
Prospective Studies
Risk Factors
ISSN:1526-632X, 1526-632X
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions. Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders. MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST. MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
AbstractList To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions.OBJECTIVETo examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions.Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders.METHODSParticipants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders.MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST.RESULTSMetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST.MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.CONCLUSIONSMetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions. Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders. MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST. MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
Author Barberger-Gateau, P
Amieva, H
Tzourio, C
Le Goff, M
Gin, H
Helmer, C
Akbaraly, T N
Raffaitin, C
Féart, C
Author_xml – sequence: 1
  givenname: C
  surname: Raffaitin
  fullname: Raffaitin, C
  email: christelle.raffaitin@isped.u-bordeaux2.fr
  organization: Diabetology–Nutrition Unit, University Hospital of Bordeaux, Pessac, France. christelle.raffaitin@isped.u-bordeaux2.fr
– sequence: 2
  givenname: C
  surname: Féart
  fullname: Féart, C
– sequence: 3
  givenname: M
  surname: Le Goff
  fullname: Le Goff, M
– sequence: 4
  givenname: H
  surname: Amieva
  fullname: Amieva, H
– sequence: 5
  givenname: C
  surname: Helmer
  fullname: Helmer, C
– sequence: 6
  givenname: T N
  surname: Akbaraly
  fullname: Akbaraly, T N
– sequence: 7
  givenname: C
  surname: Tzourio
  fullname: Tzourio, C
– sequence: 8
  givenname: H
  surname: Gin
  fullname: Gin, H
– sequence: 9
  givenname: P
  surname: Barberger-Gateau
  fullname: Barberger-Gateau, P
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21288982$$D View this record in MEDLINE/PubMed
BookMark eNpNkM9LwzAcxYNM3A_9D0Ry89SZpE2bepOxqTDdwYneSvLNty7SprNphf73Dpzg6T0en_cOb0pGvvFIyCVncy64uHl7Xs-ZYTzGmCvBTJbK9IRMuBRplMbiffTPj8k0hE_GDkGWn5Hxoa9UrsSEbJ6w06apHNAweNs2NVLtLYXmw7vOfSO1CJXzSJ2nqxY97ChWFttwS7sd0u2uRYwWrhvoS9fb4ZyclroKeHHUGXldLbeLh2i9uX9c3K0jiOO0i2wJMtFS6gQgs5nlpUHGOeQlZxa5AgSRl2mscqmZUInODPBEmxwYWJMbMSPXv7v7tvnqMXRF7QJgVWmPTR8KJZlMJRPiQF4dyd7UaIt962rdDsXfB-IH-HxiZg
CitedBy_id crossref_primary_10_1016_j_jagp_2016_05_008
crossref_primary_10_1111_j_1872_034X_2012_01076_x
crossref_primary_10_1177_0898264320916959
crossref_primary_10_1080_13546805_2025_2503445
crossref_primary_10_1093_rheumatology_keab787
crossref_primary_10_1093_ageing_afv053
crossref_primary_10_3233_JAD_170179
crossref_primary_10_1016_j_ajp_2020_102185
crossref_primary_10_2217_ahe_11_19
crossref_primary_10_3390_brainsci12020255
crossref_primary_10_1161_CIR_0000000000000152
crossref_primary_10_1161_CIR_0000000000000350
crossref_primary_10_1016_j_gde_2014_05_004
crossref_primary_10_2174_0115672050370810250430112549
crossref_primary_10_1007_s11892_014_0476_2
crossref_primary_10_1097_QAD_0000000000001017
crossref_primary_10_1016_j_jad_2022_11_067
crossref_primary_10_1007_s12603_013_0010_2
crossref_primary_10_1080_23279095_2017_1363039
crossref_primary_10_1186_s12888_024_06054_x
crossref_primary_10_1161_CIR_0000000000000558
crossref_primary_10_3390_jcm9010122
crossref_primary_10_1016_j_jalz_2011_11_007
crossref_primary_10_1111_appy_12019
crossref_primary_10_1007_s40263_020_00781_x
crossref_primary_10_1016_j_annepidem_2011_12_003
crossref_primary_10_1097_NMD_0000000000000124
crossref_primary_10_1111_j_1463_1326_2011_01490_x
crossref_primary_10_1007_s12603_020_1333_4
crossref_primary_10_1371_journal_pone_0194990
crossref_primary_10_1016_j_archger_2017_07_002
crossref_primary_10_1111_j_1751_7176_2011_00577_x
crossref_primary_10_1016_j_archger_2012_02_002
crossref_primary_10_1016_j_neubiorev_2013_03_005
crossref_primary_10_1007_s10072_023_06835_4
crossref_primary_10_1016_j_neurobiolaging_2012_02_022
crossref_primary_10_2147_NDT_S367392
crossref_primary_10_3390_nu16050612
crossref_primary_10_1016_j_jalz_2017_07_757
crossref_primary_10_1159_000362656
crossref_primary_10_3233_JAD_190261
crossref_primary_10_1111_j_1447_0594_2011_00818_x
crossref_primary_10_1371_journal_pone_0184313
crossref_primary_10_1007_s11011_012_9306_x
crossref_primary_10_1159_000509124
crossref_primary_10_1038_s41440_023_01271_5
crossref_primary_10_1159_000362265
crossref_primary_10_1017_S0029665112002959
crossref_primary_10_1111_j_2040_1124_2012_00234_x
crossref_primary_10_1371_journal_pone_0024325
crossref_primary_10_1111_imj_12588
crossref_primary_10_1007_s00415_016_8292_z
crossref_primary_10_1161_CIR_0000000000000485
crossref_primary_10_1007_s00406_019_01017_w
crossref_primary_10_1111_jgs_13358
crossref_primary_10_1007_s12264_013_1408_x
crossref_primary_10_1016_j_neuroimage_2020_117324
crossref_primary_10_1186_s13098_023_01080_3
crossref_primary_10_1002_oby_23400
crossref_primary_10_1007_s11357_022_00640_1
crossref_primary_10_3390_jcm13092571
crossref_primary_10_1016_j_psychres_2019_03_036
crossref_primary_10_3233_JAD_150256
crossref_primary_10_1161_CIR_0000000000000659
crossref_primary_10_5665_sleep_2070
crossref_primary_10_1016_j_jagp_2017_02_004
crossref_primary_10_1080_23311908_2021_1913878
crossref_primary_10_1186_s13578_021_00646_w
crossref_primary_10_1186_1475_2891_11_99
crossref_primary_10_1016_j_psyneuen_2017_04_014
crossref_primary_10_1016_j_numecd_2025_104018
crossref_primary_10_3389_fpsyg_2022_981379
crossref_primary_10_1371_journal_pone_0188173
crossref_primary_10_1016_j_jagp_2019_01_214
crossref_primary_10_1016_j_advnut_2023_04_003
crossref_primary_10_1007_s00018_017_2542_9
crossref_primary_10_3390_nu14081535
crossref_primary_10_1016_j_jalz_2013_01_001
crossref_primary_10_1007_s40520_019_01322_3
crossref_primary_10_1016_j_arr_2014_09_003
crossref_primary_10_1016_j_yfrne_2014_01_002
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1212/WNL.0b013e31820b7656
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
EISSN 1526-632X
ExternalDocumentID 21288982
Genre Multicenter Study
Comparative Study
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
.55
.XZ
.Z2
01R
0R~
123
1J1
29N
354
3PY
4Q1
4Q2
4Q3
53G
5RE
5VS
6PF
77Y
A9M
AAAXR
AAGIX
AAHPQ
AAIQE
AAJCS
AAMOA
AAMTA
AAQKA
AARTV
AASCR
AASOK
AASXQ
AAWTL
AAXQO
AAYEP
ABBLC
ABIVO
ABJNI
ABOCM
ABPXF
ABVCZ
ABXYN
ABZZY
ACBKD
ACCJW
ACDDN
ACGFS
ACILI
ACLDA
ACOAL
ACWRI
ACXJB
ACZKN
ADGGA
ADKSD
ADNKB
ADSXY
AE6
AEBDS
AENEX
AFDTB
AFEXH
AFFNX
AFNMH
AFUWQ
AGINI
AHOMT
AHQNM
AHQVU
AHVBC
AIJEX
AJCLO
AKCTQ
AKULP
AKWKN
ALMA_UNASSIGNED_HOLDINGS
AMJPA
AMKUR
AMNEI
AOHHW
BOYCO
BQLVK
BYPQX
C45
CGR
CS3
CUY
CVF
DIWNM
DU5
E.X
EBS
ECM
EIF
EJD
ERAAH
EX3
F2K
F2L
F2M
F2N
F5P
FCALG
FW0
GQDEL
HZ~
IKYAY
IN~
JF7
KD2
KMI
L-C
L7B
N9A
NEJ
NPM
N~7
N~B
O9-
OAG
OAH
OBH
ODMTH
OHH
OHYEH
OL1
OLB
OLH
OLU
OLV
OLY
OLZ
OPX
OVD
OVDNE
OVIDH
OVLEI
OWU
OWV
OWW
OWX
OWY
OWZ
OXXIT
P2P
RLZ
RXW
SJN
TEORI
V2I
VVN
W3M
WH7
WOQ
WOW
X7M
XOL
XSW
XXN
XYM
XYN
YBU
YFH
~9M
7X8
ID FETCH-LOGICAL-c336t-dfc54a55a4cc7d7d1fbe011c9f10de18cec29f63895a0284a7bc14ab9c0cdb9b2
IEDL.DBID 7X8
ISICitedReferencesCount 98
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000287127100007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1526-632X
IngestDate Sun Nov 09 09:57:09 EST 2025
Wed Dec 03 14:56:48 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c336t-dfc54a55a4cc7d7d1fbe011c9f10de18cec29f63895a0284a7bc14ab9c0cdb9b2
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
PMID 21288982
PQID 850565022
PQPubID 23479
ParticipantIDs proquest_miscellaneous_850565022
pubmed_primary_21288982
PublicationCentury 2000
PublicationDate 2011-02-08
PublicationDateYYYYMMDD 2011-02-08
PublicationDate_xml – month: 02
  year: 2011
  text: 2011-02-08
  day: 08
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Neurology
PublicationTitleAlternate Neurology
PublicationYear 2011
SSID ssj0015279
Score 2.3611023
Snippet To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions....
To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 518
SubjectTerms Aged
Cognition Disorders - epidemiology
Cognition Disorders - etiology
Cognition Disorders - psychology
Cohort Studies
Female
Follow-Up Studies
France - epidemiology
Humans
Longitudinal Studies
Male
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - psychology
Neuropsychological Tests
Prospective Studies
Risk Factors
Title Metabolic syndrome and cognitive decline in French elders: the Three-City Study
URI https://www.ncbi.nlm.nih.gov/pubmed/21288982
https://www.proquest.com/docview/850565022
Volume 76
WOSCitedRecordID wos000287127100007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV05T8MwFLaAIsTCfZRLHlit5nJssyBUUTHQ0KGIbJFPUQmlhRQk_j3PSdpOiIHFmSxFz5_f-_xOhK6ZMtbxVJDAAoITxQQRWkoSW8FCoVwqE1UPm2BZxvNcjNrcnKpNq1zoxFpRm6n2PvIe96aagsW5nb0TPzTKB1fbCRrrqBMDk_GgZvkqiECjutUefFOSxlHeVs6Bsu69ZI8rF2AUKJbS9HeOWduawe4__3IP7bQkE981qNhHa7Y8QFvDNox-iJ6Gdg6H_zbReNGxAMvS4GUuETbWl0xaPCnxwNcDvmLrx3lXNxgIIx4DACzpA4HHPg_x-wg9D-7H_QfSTlYgOo7TOTFO00RSKhOtmWEmdMrCRdfChYGxIddWR8J5MkMlEJBEMqXDRCqhA22UUNEx2iinpT1FWMW-I5CjkTMiEfC4CoDiwSOPSyqZZLSL8EJSBSDXhyNkaaefVbGUVRedNNIuZk2HjQKOiHPBo7O_N5-j7cbNG5GAX6COg1trL9Gm_ppPqo-rGhGwZqPhD-D1wDI
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Metabolic+syndrome+and+cognitive+decline+in+French+elders%3A+the+Three-City+Study&rft.jtitle=Neurology&rft.au=Raffaitin%2C+C&rft.au=F%C3%A9art%2C+C&rft.au=Le+Goff%2C+M&rft.au=Amieva%2C+H&rft.date=2011-02-08&rft.issn=1526-632X&rft.eissn=1526-632X&rft.volume=76&rft.issue=6&rft.spage=518&rft_id=info:doi/10.1212%2FWNL.0b013e31820b7656&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1526-632X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1526-632X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1526-632X&client=summon