Change surface regression for nonlinear subgroup identification with application to warfarin pharmacogenomics data

Pharmacogenomics stands as a pivotal driver toward personalized medicine, aiming to optimize drug efficacy while minimizing adverse effects by uncovering the impact of genetic variations on inter-individual outcome variability. Despite its promise, the intricate landscape of drug metabolism introduc...

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Bibliographic Details
Published in:	Biometrics Vol. 81; no. 1
Main Authors:	Liu, Pan, Li, Yaguang, Li, Jialiang
Format:	Journal Article
Language:	English
Published:	England 07.01.2025
Subjects:	Algorithms Anticoagulants - administration & dosage Computer Simulation Humans Models, Statistical Nonlinear Dynamics Pharmacogenetics - methods Pharmacogenetics - statistics & numerical data Precision Medicine Regression Analysis Warfarin - administration & dosage Warfarin - pharmacokinetics change surface pharmacogenomics warfarin dosing treatment recommendation personalized medicine subgroup identification
ISSN:	0006-341X, 1541-0420, 1541-0420
Online Access:	Get full text
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