European Biological Variation Study (EuBIVAS): Within- and Between-Subject Biological Variation Data for 15 Frequently Measured Proteins

The European Biological Variation Study (EuBIVAS) was established to deliver rigorously determined data for biological variation (BV). Here, EuBIVAS-based BV estimates are provided for α -acid glycoprotein, α -antitrypsin, albumin, β -microglobulin, ceruloplasmin, complement component 3, complement...

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Vydáno v:Clinical chemistry (Baltimore, Md.) Ročník 65; číslo 8; s. 1031 - 1041
Hlavní autoři: Carobene, Anna, Aarsand, Aasne K, Guerra, Elena, Bartlett, William A, Coşkun, Abdurrahman, Díaz-Garzón, Jorge, Fernandez-Calle, Pilar, Jonker, Niels, Locatelli, Massimo, Sandberg, Sverre, Ceriotti, Ferruccio
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Oxford University Press 01.08.2019
Témata:
a1-antitrypsin
Acids
Acute phase proteins
Acute-Phase Proteins - analysis
Adult
Aged
Biological variation
Biological Variation, Population - physiology
Blood Proteins - analysis
C-reactive protein
C-Reactive Protein - analysis
Cardiovascular diseases
Ceruloplasmin
Clinical outcomes
Cystatin C
Cystatin C - blood
Data analysis
Estimates
Female
Glycoproteins
Haptoglobin
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunoglobulins - blood
Inflammation
Laboratories
Male
Middle Aged
Older people
Outliers (statistics)
Proteins
Receptors, Transferrin - blood
Risk analysis
Risk factors
Serum Albumin - analysis
Studies
Transferrin
Transferrin - analysis
Transferrins
Variance analysis
Variation
β2 Microglobulin
Italy
Netherlands
ISSN:0009-9147, 1530-8561, 1530-8561
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Shrnutí:The European Biological Variation Study (EuBIVAS) was established to deliver rigorously determined data for biological variation (BV). Here, EuBIVAS-based BV estimates are provided for α -acid glycoprotein, α -antitrypsin, albumin, β -microglobulin, ceruloplasmin, complement component 3, complement component 4, C-reactive protein (CRP), cystatin C, haptoglobin, IgA, IgG, IgM, soluble transferrin receptor (sTfR), and transferrin (Trf), together with their associated analytical performance specifications (APSs) and reference change values (RCVs). Serum samples from weekly blood samplings of 91 healthy study participants (38 males and 53 females, ages 21-69 years old) over 10 consecutive weeks in 6 European laboratories were stored at -80 °C before duplicate analysis on a Roche Cobas c702. Outlier and variance homogeneity analyses were performed followed by CV-ANOVA on trend-corrected data if relevant, to determine BV and analytical variation estimates with CI and the associated RCV. For the acute phase proteins, several participants experienced mild inflammatory episodes during the study, requiring exclusion of 7% of the 25290 results. Within-subject BV (CV ) estimates for specific proteins obtained in our study were lower than those available in the online 2014 BV database, except for Trf, whereas between-subject BV (CV ) estimates were similar. CV and CV estimates for sTfR, which have not previously been published, were 6.0% and 19.1%, respectively. In addition to new BV estimates for sTfR, this EuBIVAS substudy generated more demanding APS for frequently requested plasma specific proteins. APS for CRP should not be calculated from BV data except when CRP is used as a risk factor for cardiovascular disease.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0009-9147
1530-8561
1530-8561
DOI:10.1373/clinchem.2019.304618