AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement

Although angiotensin IV (Ang IV) was thought initially to be an inactive product of Ang II degradation, it was subsequently shown that the hexapeptide markedly enhances learning and memory in normal rodents and reverses the memory deficits seen in animal models of amnesia. These central nervous syst...

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Bibliographic Details
Published in:	Trends in endocrinology and metabolism Vol. 14; no. 2; pp. 72 - 77
Main Authors:	Albiston, Anthony L, Mustafa, Tomris, McDowall, Sharon G, Mendelsohn, Frederick A.O, Lee, Joohyung, Chai, Siew Yeen
Format:	Journal Article
Language:	English
Published:	London Elsevier 01.03.2003
Subjects:	Aminopeptidases - metabolism Anatomical correlates of behavior Angiotensin II - administration & dosage Angiotensin II - analogs & derivatives Angiotensin II - metabolism Angiotensin II - physiology Animals Behavioral psychophysiology Biological and medical sciences Brain - metabolism Cystinyl Aminopeptidase Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Injections, Intraventricular Insulin - physiology Memory - drug effects Memory - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Angiotensin - metabolism Signal Transduction Tissue Distribution Learning Peptidases Acquisition process Enzyme Aminopeptidases Memory Hydrolases Review Angiotensin receptor
ISSN:	1043-2760
Online Access:	Get full text
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