Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity

Exposure to illicit cocaine and its frequent adulterant, levamisole, is associated with ANCAs targeting neutrophil elastase (NE), neutropenia and vasculitic/thrombotic skin purpura. The mechanisms of cocaine/levamisole-associated autoimmunity (CLAA) are unknown. The aim of this study was to assess t...

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Veröffentlicht in:	Rheumatology (Oxford, England) Jg. 56; H. 4; S. 638
Hauptverfasser:	Lood, Christian, Hughes, Grant C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.04.2017
Schlagworte:	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - chemically induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology Autoantigens - drug effects Autoantigens - immunology Autoimmunity - drug effects Autoimmunity - immunology Case-Control Studies Cocaine - adverse effects Cocaine - immunology Cocaine-Related Disorders - immunology Dopamine Uptake Inhibitors - adverse effects Dopamine Uptake Inhibitors - immunology Enzyme-Linked Immunosorbent Assay Extracellular Traps - drug effects Extracellular Traps - immunology Extracellular Traps - metabolism Humans Immunoglobulin G - metabolism Levamisole - adverse effects Levamisole - immunology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism drug-induced rheumatic disease vasculitis autoantibodies neutrophils autoantigens anti-neutrophil cytoplasm antibody
ISSN:	1462-0332, 1462-0332
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