Progression of experimental peri‐implantitis in guided bone regeneration and pristine bone: A preclinical in vivo study

Background Guided bone regeneration (GBR) is the most widely used technique for overcoming the deficiency of alveolar bone. However, the progression of peri‐implantitis in regenerative and pristine bone sites has not been fully investigated. The aim of this study is to compare experimental peri‐impl...

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Published in:Journal of periodontology (1970) Vol. 94; no. 8; pp. 1032 - 1044
Main Authors: Ko, Young‐Chang, Lee, Jungwon, Lee, Dongseob, Seol, Yang‐Jo, Koo, Ki‐Tae, Lee, Yong‐Moo
Format: Journal Article
Language:English
Published: United States 01.08.2023
Subjects:
bone regeneration
guided bone regeneration
macrophage
osteoclast
periimplantitis
guided bone regeneration
bone regeneration
macrophage
osteoclast
periimplantitis
ISSN:0022-3492, 1943-3670, 1943-3670
Online Access:Get full text
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Summary:Background Guided bone regeneration (GBR) is the most widely used technique for overcoming the deficiency of alveolar bone. However, the progression of peri‐implantitis in regenerative and pristine bone sites has not been fully investigated. The aim of this study is to compare experimental peri‐implantitis around implants placed in pristine bone and GBR sites. Methods Bilateral  mandibular first molars were extracted from six beagle dogs, and standardized horizontal ridge defect was simultaneously created at predetermined site in unilateral mandible. After 8 weeks, guided bone regeneration procedure was conducted at the defect site. After 16 weeks, implants (ϕ 3.6×8.0 mm) were placed at both extracted sites. This study included 3 months of active breakdown and another 3 months of spontaneous progression period. Radiographs were taken at each phase and specimens were obtained for histological, immunohistochemical, and polarized light microscopic analysis. Results Marginal bone loss around implant did not show the significant differences between pristine bone and GBR sites during spontaneous progression period. In immunohistochemical analysis, inflammatory and immune‐related cells were predominantly detected in peri‐implantitis‒affected area rather than unaffected area. In the polarized light microscopic analysis, substantial reductions in the amount and thickness of collagen fibers were observed in peri‐implantitis‒affected area compared with unaffected tissues. However, there were no significant differences in histological, immunohistochemical, polarized light microscopic outcomes between pristine bone and GBR sites. Conclusion Previous hard tissue grafting at the implant sites did not affect experimental peri‐implantitis and exhibited similar radiographic, histological, immunohistochemical, and polarized light microscopic outcomes compared with those of pristine bone sites.
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ISSN:0022-3492
1943-3670
1943-3670
DOI:10.1002/JPER.22-0586