Group-common and individual-specific effects of structure–function coupling in human brain networks with graph neural networks

The human cerebral cortex is organized into functionally segregated but synchronized regions bridged by the structural connectivity of white matter pathways. While structure–function coupling has been implicated in cognitive development and neuropsychiatric disorders, it remains unclear to what exte...

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Vydáno v:	Imaging neuroscience (Cambridge, Mass.) Ročník 2
Hlavní autoři:	Chen, Peiyu, Yang, Hang, Zheng, Xin, Jia, Hai, Hao, Jiachang, Xu, Xiaoyu, Li, Chao, He, Xiaosong, Chen, Runsen, Okubo, Tatsuo S., Cui, Zaixu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	255 Main Street, 9th Floor, Cambridge, Massachusetts 02142, USA MIT Press 02.12.2024
Témata:	diffusion MRI functional MRI graph neural networks individual effects sensorimotor-association cortical axis structure–function coupling diffusion MRI functional MRI graph neural networks individual effects sensorimotor-association cortical axis structure–function coupling
ISSN:	2837-6056, 2837-6056
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Shrnutí:	The human cerebral cortex is organized into functionally segregated but synchronized regions bridged by the structural connectivity of white matter pathways. While structure–function coupling has been implicated in cognitive development and neuropsychiatric disorders, it remains unclear to what extent the structure–function coupling reflects a group-common characteristic or varies across individuals, at both the global and regional brain levels. By leveraging two independent, high-quality datasets, we found that the graph neural network accurately predicted unseen individuals’ functional connectivity from structural connectivity, reflecting a strong structure–function coupling. This coupling was primarily driven by network topology and was substantially stronger than that of the correlation approaches. Moreover, we observed that structure–function coupling was dominated by group-common effects, with subtle yet significant individual-specific effects. The regional group and individual effects of coupling were hierarchically organized across the cortex along a sensorimotor-association axis, with lower group and higher individual effects in association cortices. These findings emphasize the importance of considering both group and individual effects in understanding cortical structure–function coupling, suggesting insights into interpreting individual differences of the coupling and informing connectivity-guided therapeutics.
Bibliografie:	2024 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributed equally as senior authors Contributed equally as first authors
ISSN:	2837-6056 2837-6056
DOI:	10.1162/imag_a_00378