Severe Sepsis and Septic Shock

Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of this disorder. Sepsis is one of the oldest and most elusive syndromes in medicine. Hippocrates claimed...

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Vydané v:	The New England journal of medicine Ročník 369; číslo 9; s. 840 - 851
Hlavní autori:	Angus, Derek C, van der Poll, Tom
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Waltham, MA Massachusetts Medical Society 29.08.2013
Edícia:	Critical Care Medicine
Predmet:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacterial diseases Bacterial sepsis Biological and medical sciences Emergency and intensive care: infection, septic shock General aspects Gram-positive bacteria Human bacterial diseases Humans Incidence Infectious diseases Intensive care Intensive care medicine Medical sciences Metabolic response Pathogenesis Resuscitation Risk Factors Sepsis Sepsis - etiology Sepsis - immunology Septic shock Shock, Septic - diagnosis Shock, Septic - etiology Shock, Septic - physiopathology Shock, Septic - therapy Streptococcus infections United States > US Infection Medicine Sepsis syndrome Bacteriosis Septic shock Severe Bacteremia
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line prístup:	Získať plný text
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Abstract	Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of this disorder. Sepsis is one of the oldest and most elusive syndromes in medicine. Hippocrates claimed that sepsis (σήψις) was the process by which flesh rots, swamps generate foul airs, and wounds fester. 1 Galen later considered sepsis a laudable event, necessary for wound healing. 2 With the confirmation of germ theory by Semmelweis, Pasteur, and others, sepsis was recast as a systemic infection, often described as “blood poisoning,” and assumed to be the result of the host's invasion by pathogenic organisms that then spread in the bloodstream. However, with the advent of modern antibiotics, germ theory did not fully explain the pathogenesis of . . .
AbstractList	Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of this disorder. Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of this disorder. Sepsis is one of the oldest and most elusive syndromes in medicine. Hippocrates claimed that sepsis (σήψις) was the process by which flesh rots, swamps generate foul airs, and wounds fester. 1 Galen later considered sepsis a laudable event, necessary for wound healing. 2 With the confirmation of germ theory by Semmelweis, Pasteur, and others, sepsis was recast as a systemic infection, often described as “blood poisoning,” and assumed to be the result of the host's invasion by pathogenic organisms that then spread in the bloodstream. However, with the advent of modern antibiotics, germ theory did not fully explain the pathogenesis of . . .
Author	van der Poll, Tom Angus, Derek C
Author_xml	– sequence: 1 givenname: Derek C surname: Angus fullname: Angus, Derek C organization: From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (D.C.A.); and the Center for Experimental and Molecular Medicine, Division of Infectious Diseases, and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam (T.P.) – sequence: 2 givenname: Tom surname: van der Poll fullname: van der Poll, Tom organization: From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (D.C.A.); and the Center for Experimental and Molecular Medicine, Division of Infectious Diseases, and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam (T.P.)
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SubjectTerms	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacterial diseases Bacterial sepsis Biological and medical sciences Emergency and intensive care: infection, septic shock General aspects Gram-positive bacteria Human bacterial diseases Humans Incidence Infectious diseases Intensive care Intensive care medicine Medical sciences Metabolic response Pathogenesis Resuscitation Risk Factors Sepsis Sepsis - etiology Sepsis - immunology Septic shock Shock, Septic - diagnosis Shock, Septic - etiology Shock, Septic - physiopathology Shock, Septic - therapy Streptococcus infections
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Title	Severe Sepsis and Septic Shock
URI	https://nejm.org/doi/full/10.1056/NEJMra1208623 https://www.ncbi.nlm.nih.gov/pubmed/23984731 https://www.proquest.com/docview/1428834780 https://www.proquest.com/docview/1429219282
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