Severe Sepsis and Septic Shock

Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of this disorder. Sepsis is one of the oldest and most elusive syndromes in medicine. Hippocrates claimed...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 369; no. 9; pp. 840 - 851
Main Authors: Angus, Derek C, van der Poll, Tom
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 29.08.2013
Series:Critical Care Medicine
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Emergency and intensive care: infection, septic shock
General aspects
Gram-positive bacteria
Human bacterial diseases
Humans
Incidence
Infectious diseases
Intensive care
Intensive care medicine
Medical sciences
Metabolic response
Pathogenesis
Resuscitation
Risk Factors
Sepsis
Sepsis - etiology
Sepsis - immunology
Septic shock
Shock, Septic - diagnosis
Shock, Septic - etiology
Shock, Septic - physiopathology
Shock, Septic - therapy
Streptococcus infections
United States > US
Infection
Medicine
Sepsis syndrome
Bacteriosis
Septic shock
Severe
Bacteremia
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of this disorder. Sepsis is one of the oldest and most elusive syndromes in medicine. Hippocrates claimed that sepsis (σήψις) was the process by which flesh rots, swamps generate foul airs, and wounds fester. 1 Galen later considered sepsis a laudable event, necessary for wound healing. 2 With the confirmation of germ theory by Semmelweis, Pasteur, and others, sepsis was recast as a systemic infection, often described as “blood poisoning,” and assumed to be the result of the host's invasion by pathogenic organisms that then spread in the bloodstream. However, with the advent of modern antibiotics, germ theory did not fully explain the pathogenesis of . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMra1208623