Lipid Solubility and Molecular Weight: Whose Idea Was That

Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative struc...

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Vydáno v:Skin pharmacology and physiology Ročník 26; číslo 4-6; s. 295 - 301
Hlavní autor: Kasting, G.B.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel, Switzerland S. Karger AG 01.01.2013
Témata:
Administration, Cutaneous
Cooper Eugene Rex
Drug Design
Eugene Rex Cooper
Further Section
History, 20th Century
History, 21st Century
Humans
Models, Biological
Molecular Weight
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Quantitative Structure-Activity Relationship
Skin - metabolism
Skin Absorption
Solubility
Skin permeability
Cooper, Gene
Quantitative structure-penetration relationship
Finite dose
Penetration enhancer
ISBN:3318024244, 9783318024241
ISSN:1660-5527, 1660-5535, 1660-5535
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Popis
Shrnutí:Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative structure-penetration relationships for chemicals contacting human skin. His ideas regarding the impact of molecular weight and lipid solubility on skin transport catalyzed the later development by Potts and Guy of the first successful skin permeability model. But Gene's most important contribution to the field was as a scientific role model and an inspirational leader who launched the careers of several young scientists, including the author of this article.
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ISBN:3318024244
9783318024241
ISSN:1660-5527
1660-5535
1660-5535
DOI:10.1159/000351956