Development of anatomically based structure for human acinus by Lindenmayer system: accurate model for gas exchange in human lung

Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model of pulmonary acinus is useful for simulation of fluid distribution, gas exchange, particle deposition, drug delivery, and detection of struc...

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Vydáno v:	European physical journal plus Ročník 136; číslo 8; s. 844
Hlavní autoři:	Abbasi, Zeinab, Bozorgmehry Boozarjomhery, Ramin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 15.08.2021 Springer Nature B.V
Témata:	Abnormalities Algorithms Alveoli Applied and Technical Physics Asymmetry Atomic Complex Systems Condensed Matter Physics Diameters Gas exchange Gases Low resistance Lungs Mathematical and Computational Physics Mechanical properties Molecular Nitrogen Optical and Plasma Physics Optimization Particle deposition Particle swarm optimization Physics Physics and Astronomy Physiology Rare gases Regular Article Theoretical Three dimensional models
ISSN:	2190-5444, 2190-5444
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Abstract	Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model of pulmonary acinus is useful for simulation of fluid distribution, gas exchange, particle deposition, drug delivery, and detection of structural abnormalities in the lungs. In this study, the stochastic parametric Lindenmayer system has been used to generate the respiratory airways filling a given space. This model takes into account the mechanical properties and details of human acinus which can accurately predict the gas distribution throughout the lungs for the first time. The procedure of finding the dimensions and orientations of airways depends on several decision variables which have been found by particle swarm optimization algorithm. A novel procedure to generate the distribution of alveoli over airways has also been proposed. The morphometric characteristics (i.e., length, diameter, and orientation of airways) of the generated structure are successfully validated with their measured counterparts published in the literature. To examine the degree of asymmetry in the developed structure, it has been used for the prediction of the inert gas washout curve (i.e., the curve of exhaled concentration of inert gas against exhaled volume). This is due to the fact that the slope at the end part of this curve (i.e., alveolar slope) and its progression through the breaths is highly function of the asymmetric pattern of the human bronchial tree. The comparison of predicted slopes with experimental data indicates that the proposed method outperforms the previously reported models. For instance, the relative error of previous models in the prediction of the first slope is ~ 87%, whereas this study gives accurate results. Graphic abstract
AbstractList	Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model of pulmonary acinus is useful for simulation of fluid distribution, gas exchange, particle deposition, drug delivery, and detection of structural abnormalities in the lungs. In this study, the stochastic parametric Lindenmayer system has been used to generate the respiratory airways filling a given space. This model takes into account the mechanical properties and details of human acinus which can accurately predict the gas distribution throughout the lungs for the first time. The procedure of finding the dimensions and orientations of airways depends on several decision variables which have been found by particle swarm optimization algorithm. A novel procedure to generate the distribution of alveoli over airways has also been proposed. The morphometric characteristics (i.e., length, diameter, and orientation of airways) of the generated structure are successfully validated with their measured counterparts published in the literature. To examine the degree of asymmetry in the developed structure, it has been used for the prediction of the inert gas washout curve (i.e., the curve of exhaled concentration of inert gas against exhaled volume). This is due to the fact that the slope at the end part of this curve (i.e., alveolar slope) and its progression through the breaths is highly function of the asymmetric pattern of the human bronchial tree. The comparison of predicted slopes with experimental data indicates that the proposed method outperforms the previously reported models. For instance, the relative error of previous models in the prediction of the first slope is ~ 87%, whereas this study gives accurate results.Graphic abstract Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model of pulmonary acinus is useful for simulation of fluid distribution, gas exchange, particle deposition, drug delivery, and detection of structural abnormalities in the lungs. In this study, the stochastic parametric Lindenmayer system has been used to generate the respiratory airways filling a given space. This model takes into account the mechanical properties and details of human acinus which can accurately predict the gas distribution throughout the lungs for the first time. The procedure of finding the dimensions and orientations of airways depends on several decision variables which have been found by particle swarm optimization algorithm. A novel procedure to generate the distribution of alveoli over airways has also been proposed. The morphometric characteristics (i.e., length, diameter, and orientation of airways) of the generated structure are successfully validated with their measured counterparts published in the literature. To examine the degree of asymmetry in the developed structure, it has been used for the prediction of the inert gas washout curve (i.e., the curve of exhaled concentration of inert gas against exhaled volume). This is due to the fact that the slope at the end part of this curve (i.e., alveolar slope) and its progression through the breaths is highly function of the asymmetric pattern of the human bronchial tree. The comparison of predicted slopes with experimental data indicates that the proposed method outperforms the previously reported models. For instance, the relative error of previous models in the prediction of the first slope is ~ 87%, whereas this study gives accurate results. Graphic abstract
ArticleNumber	844
Author	Bozorgmehry Boozarjomhery, Ramin Abbasi, Zeinab
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Cites_doi	10.1183/09031936.00069712 10.1016/S1569-9048(02)00136-2 10.1085/jgp.118.3.267 10.1016/j.cmpb.2020.105613 10.1243/09544119JEIM309 10.1140/epjp/s13360-020-01001-7 10.1016/0034-5687(78)90104-4 10.3109/08958378.2012.654857 10.1002/ar.b.10034 10.1152/jappl.1999.87.6.2207 10.1016/0022-5193(68)90079-9 10.1002/aja.1001620304 10.1152/japplphysiol.00386.2009 10.1002/ar.1092200410 10.1002/ar.21161 10.1152/japplphysiol.00768.2011 10.1152/jappl.1975.38.6.983 10.1115/1.4006809 10.1152/jappl.1971.31.3.386 10.1016/j.apm.2020.08.051 10.1115/1.3049481 10.1016/j.cmpb.2016.04.021 10.1152/jappl.1985.59.3.838 10.1016/j.ejps.2017.09.016 10.1152/japplphysiol.01017.2014 10.1016/0034-5687(93)90001-Q 10.1016/j.pbi.2003.11.007 10.1016/S0034-5687(01)00238-9 10.1152/jappl.2000.89.5.1859 10.1103/PhysRevLett.95.168101 10.1016/0034-5687(70)90094-0 10.1016/j.ejps.2017.09.033 10.1152/jappl.1975.38.6.990 10.1007/978-3-642-87553-3 10.1016/S0034-5687(01)00239-0 10.1038/nature02287 10.1152/jappl.2000.88.6.2260 10.1080/08958370701626501 10.14814/phy2.13709 10.1152/japplphysiol.00541.2015 10.1016/0898-1221(77)90061-X 10.1016/j.compbiomed.2015.03.032 10.1016/j.apm.2012.10.055 10.1016/j.resp.2005.03.005 10.1021/acs.iecr.0c05699 10.1140/epjp/s13360-021-01175-8 10.1007/11795018_13
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References	McDonough, Knudsen, Wright, Elliott, Ochs, Hogg (CR38) 2015; 118 Davoodi, Boozarjomehry (CR31) 2016; 132 Crawford, Makowska, Paiva, Engel (CR43) 1985; 59 Haefeli-Bleuer, Weibel (CR1) 1988; 220 Tawhai, Hunter (CR42) 2001; 127 Hansen, Ampaya, Bryant, Navin (CR3) 1975; 38 Yablonskiy, Sukstanskii, Woods, Gierada, Quirk, Hogg (CR7) 2009; 107 Kitaoka, Tamura, Takaki (CR13) 2000; 88 Dutrieue, Vanholsbeeck, Verbanck, Paiva (CR19) 2000; 89 Kitaoka, Takaki, Suki (CR32) 1999; 87 Mauroy, Filoche, Weibel, Sapoval (CR37) 2004; 427 Hofemeier, Koshiyama, Wada, Sznitman (CR16) 2018; 113 Asgharian, Price (CR26) 2007; 19 Pedley, Schroter, Sudlow (CR35) 1970; 9 Koullapis, Hofemeier, Sznitman, Kassinos (CR17) 2018; 113 Majumdar, Alencar, Buldyrev, Hantos, Lutchen, Stanley (CR18) 2005; 95 Sznitman, Heimsch, Wildhaber, Tsuda, Rösgen (CR14) 2009; 131 Pilou, Antonopoulos, Makris, Neofytou, Tsangaris, Housiadas (CR27) 2013; 37 Agujetas, Barrio-Perotti, Ferrera, Pandal-Blanco, Walters, Fernández-Tena (CR9) 2020; 196 Borhan, Motevalian, Ultman, Bascom, Borhan (CR23) 2021; 91 Prusinkiewicz, Lindenmayer (CR30) 2012 Leeming, Schroter (CR12) 2008; 222 Robinson, Latzin, Verbanck, Hall, Horsley, Gappa (CR22) 2013; 41 Azen, Margolick, Sherwin (CR24) 1977; 3 Weibel, Federspiel, Fryder-Doffey, Hsia, König, Stalder-Navarro (CR36) 1993; 93 Litzlbauer, Korbel, Kline, Jorgensen, Eaker, Bohle (CR6) 2010; 293 Parker, Horsfield, Cumming (CR40) 1971; 31 Hansen, Ampaya (CR4) 1975; 38 Tawhai, Hunter (CR10) 2001; 127 CR29 Weibel, Cournand, Richards (CR21) 1963 CR25 CR47 Quirk, Sukstanskii, Woods, Lutey, Conradi, Gierada (CR8) 2015; 120 Henry, Llapur, Tsuda, Tepper (CR15) 2012; 134 Hajari, Yablonskiy, Sukstanskii, Quirk, Conradi, Woods (CR41) 2011; 112 Asgharian, Price, Schroeter, Kimbell, Singal (CR28) 2012; 24 Foy, Gonem, Brightling, Siddiqui, Kay (CR34) 2018; 6 Prusinkiewicz (CR48) 2004; 7 Tawhai, Burrowes (CR20) 2003; 275 Luijendijk, van der Grinten (CR44) 2002; 133 Gehr, Bachofen, Weibel (CR39) 1978; 32 Abbasi, Bozorgmehry Boozarjomhery (CR2) 2021; 136 Lindenmayer (CR45) 1968; 18 Weibel, Sapoval, Filoche (CR33) 2005; 148 Zamir (CR46) 2001; 118 Schreider, Raabe (CR5) 1981; 162 Koshiyama, Wada (CR11) 2015; 62 S Luijendijk (1764_CR44) 2002; 133 JE Hansen (1764_CR3) 1975; 38 A Davoodi (1764_CR31) 2016; 132 B Dutrieue (1764_CR19) 2000; 89 PD Robinson (1764_CR22) 2013; 41 BH Foy (1764_CR34) 2018; 6 1764_CR25 1764_CR47 MH Tawhai (1764_CR20) 2003; 275 P Koullapis (1764_CR17) 2018; 113 1764_CR29 P Prusinkiewicz (1764_CR48) 2004; 7 B Mauroy (1764_CR37) 2004; 427 A Leeming (1764_CR12) 2008; 222 MH Tawhai (1764_CR42) 2001; 127 A Lindenmayer (1764_CR45) 1968; 18 M Pilou (1764_CR27) 2013; 37 B Asgharian (1764_CR26) 2007; 19 P Hofemeier (1764_CR16) 2018; 113 S Azen (1764_CR24) 1977; 3 S Borhan (1764_CR23) 2021; 91 Z Abbasi (1764_CR2) 2021; 136 J Sznitman (1764_CR14) 2009; 131 AJ Hajari (1764_CR41) 2011; 112 T Pedley (1764_CR35) 1970; 9 MH Tawhai (1764_CR10) 2001; 127 K Koshiyama (1764_CR11) 2015; 62 R Agujetas (1764_CR9) 2020; 196 F Henry (1764_CR15) 2012; 134 H Kitaoka (1764_CR32) 1999; 87 M Zamir (1764_CR46) 2001; 118 B Haefeli-Bleuer (1764_CR1) 1988; 220 ER Weibel (1764_CR21) 1963 B Asgharian (1764_CR28) 2012; 24 P Prusinkiewicz (1764_CR30) 2012 JE McDonough (1764_CR38) 2015; 118 JD Quirk (1764_CR8) 2015; 120 H Kitaoka (1764_CR13) 2000; 88 ER Weibel (1764_CR33) 2005; 148 ER Weibel (1764_CR36) 1993; 93 JE Hansen (1764_CR4) 1975; 38 JP Schreider (1764_CR5) 1981; 162 HD Litzlbauer (1764_CR6) 2010; 293 A Crawford (1764_CR43) 1985; 59 P Gehr (1764_CR39) 1978; 32 H Parker (1764_CR40) 1971; 31 DA Yablonskiy (1764_CR7) 2009; 107 A Majumdar (1764_CR18) 2005; 95
References_xml	– volume: 41 start-page: 507 year: 2013 end-page: 522 ident: CR22 article-title: Consensus statement for inert gas washout measurement using multiple-and single-breath tests publication-title: Eur. Respir. J. doi: 10.1183/09031936.00069712 – volume: 133 start-page: 99 year: 2002 end-page: 107 ident: CR44 article-title: Collateral gas transport by diffusion across tissue in the healthy, human lung; effects on dead space publication-title: Respir. Physiol. Neurobiol. doi: 10.1016/S1569-9048(02)00136-2 – volume: 118 start-page: 267 year: 2001 end-page: 276 ident: CR46 article-title: Arterial branching within the confines of fractal L-system formalism publication-title: J. Gen. Physiol. doi: 10.1085/jgp.118.3.267 – volume: 196 start-page: 105613 year: 2020 ident: CR9 article-title: Construction of a hybrid lung model by combining a real geometry of the upper airways and an idealized geometry of the lower airways publication-title: Comput. Methods Programs Biomed. doi: 10.1016/j.cmpb.2020.105613 – volume: 222 start-page: 429 year: 2008 end-page: 437 ident: CR12 article-title: A model morphology of the pulmonary acinus publication-title: Proc. Inst. Mech. Eng. [H] doi: 10.1243/09544119JEIM309 – ident: CR47 – volume: 136 start-page: 1 year: 2021 end-page: 30 ident: CR2 article-title: Modeling of human conducting airways by stochastic parametric L-system publication-title: Eur. Phys. J. Plus doi: 10.1140/epjp/s13360-020-01001-7 – volume: 32 start-page: 121 year: 1978 end-page: 140 ident: CR39 article-title: The normal human lung: ultrastructure and morphometric estimation of diffusion capacity publication-title: Respir. Physiol. doi: 10.1016/0034-5687(78)90104-4 – volume: 24 start-page: 182 year: 2012 end-page: 193 ident: CR28 article-title: A lung dosimetry model of vapor uptake and tissue disposition publication-title: Inhal. Toxicol. doi: 10.3109/08958378.2012.654857 – volume: 275 start-page: 207 year: 2003 end-page: 218 ident: CR20 article-title: Developing integrative computational models of pulmonary structure publication-title: Anat. Rec. Part B New Anat. Off. Publ. Am. Assoc. Anat. doi: 10.1002/ar.b.10034 – volume: 87 start-page: 2207 year: 1999 end-page: 2217 ident: CR32 article-title: A three-dimensional model of the human airway tree publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1999.87.6.2207 – volume: 18 start-page: 280 year: 1968 end-page: 299 ident: CR45 article-title: Mathematical models for cellular interactions in development I. Filaments with one-sided inputs publication-title: J. Theor. Biol. doi: 10.1016/0022-5193(68)90079-9 – volume: 162 start-page: 221 year: 1981 end-page: 232 ident: CR5 article-title: Structure of the human respiratory acinus publication-title: Am. J. Anat. doi: 10.1002/aja.1001620304 – ident: CR29 – volume: 107 start-page: 1258 year: 2009 end-page: 1265 ident: CR7 article-title: Quantification of lung microstructure with hyperpolarized 3He diffusion MRI publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00386.2009 – volume: 220 start-page: 401 year: 1988 end-page: 414 ident: CR1 article-title: Morphometry of the human pulmonary acinus publication-title: Anat. Rec. doi: 10.1002/ar.1092200410 – volume: 293 start-page: 1607 year: 2010 end-page: 1614 ident: CR6 article-title: Synchrotron-based micro-CT imaging of the human lung acinus publication-title: Anat. Rec. doi: 10.1002/ar.21161 – ident: CR25 – volume: 112 start-page: 937 year: 2011 end-page: 943 ident: CR41 article-title: Morphometric changes in the human pulmonary acinus during inflation publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00768.2011 – volume: 38 start-page: 983 year: 1975 end-page: 989 ident: CR3 article-title: Branching pattern of airways and air spaces of a single human terminal bronchiole publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1975.38.6.983 – volume: 134 start-page: 061001 year: 2012 ident: CR15 article-title: Numerical modelling and analysis of peripheral airway asymmetry and ventilation in the human adult lung publication-title: J. Biomech. Eng. doi: 10.1115/1.4006809 – year: 2012 ident: CR30 publication-title: The Algorithmic Beauty of Plants – volume: 31 start-page: 386 year: 1971 end-page: 391 ident: CR40 article-title: Morphology of distal airways in the human lung publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1971.31.3.386 – volume: 91 start-page: 58 year: 2021 end-page: 73 ident: CR23 article-title: A patient-specific model of reactive air pollutant uptake in proximal airways of the lung: effect of tracheal deviation publication-title: Appl. Math. Model. doi: 10.1016/j.apm.2020.08.051 – volume: 131 start-page: 031010 year: 2009 ident: CR14 article-title: Respiratory flow phenomena and gravitational deposition in a three-dimensional space-filling model of the pulmonary acinar tree publication-title: J. Biomech. Eng. doi: 10.1115/1.3049481 – volume: 132 start-page: 1 year: 2016 end-page: 10 ident: CR31 article-title: Developmental model of an automatic production of the human bronchial tree based on L-system publication-title: Comput. Methods Programs Biomed. doi: 10.1016/j.cmpb.2016.04.021 – volume: 59 start-page: 838 year: 1985 end-page: 846 ident: CR43 article-title: Convection-and diffusion-dependent ventilation maldistribution in normal subjects publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1985.59.3.838 – volume: 113 start-page: 132 year: 2018 end-page: 144 ident: CR17 article-title: An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.09.016 – volume: 118 start-page: 1429 year: 2015 end-page: 1434 ident: CR38 article-title: Regional differences in alveolar density in the human lung are related to lung height publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.01017.2014 – volume: 93 start-page: 125 year: 1993 end-page: 149 ident: CR36 article-title: Morphometric model for pulmonary diffusing capacity I. Membrane diffusing capacity publication-title: Respir. Physiol. doi: 10.1016/0034-5687(93)90001-Q – volume: 7 start-page: 79 year: 2004 end-page: 83 ident: CR48 article-title: Modeling plant growth and development publication-title: Curr. Opin. Plant Biol. doi: 10.1016/j.pbi.2003.11.007 – volume: 127 start-page: 241 year: 2001 end-page: 248 ident: CR10 article-title: Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus publication-title: Respir. Physiol. doi: 10.1016/S0034-5687(01)00238-9 – volume: 89 start-page: 1859 year: 2000 end-page: 1867 ident: CR19 article-title: A human acinar structure for simulation of realistic alveolar plateau slopes publication-title: J. Appl. Physiol. doi: 10.1152/jappl.2000.89.5.1859 – volume: 95 start-page: 168101 year: 2005 ident: CR18 article-title: Relating airway diameter distributions to regular branching asymmetry in the lung publication-title: Phys. Rev. Lett. doi: 10.1103/PhysRevLett.95.168101 – volume: 9 start-page: 387 year: 1970 end-page: 405 ident: CR35 article-title: The prediction of pressure drop and variation of resistance within the human bronchial airways publication-title: Respir. Physiol. doi: 10.1016/0034-5687(70)90094-0 – volume: 113 start-page: 53 year: 2018 end-page: 63 ident: CR16 article-title: One (sub-) acinus for all: fate of inhaled aerosols in heterogeneous pulmonary acinar structures publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.09.033 – volume: 38 start-page: 990 year: 1975 end-page: 995 ident: CR4 article-title: Human air space shapes, sizes, areas, and volumes publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1975.38.6.990 – year: 1963 ident: CR21 publication-title: Morphometry of the Human Lung doi: 10.1007/978-3-642-87553-3 – volume: 127 start-page: 249 year: 2001 end-page: 258 ident: CR42 article-title: Multibreath washout analysis: modelling the influence of conducting airway asymmetry publication-title: Respir. Physiol. doi: 10.1016/S0034-5687(01)00239-0 – volume: 427 start-page: 633 year: 2004 ident: CR37 article-title: An optimal bronchial tree may be dangerous publication-title: Nature doi: 10.1038/nature02287 – volume: 88 start-page: 2260 year: 2000 end-page: 2268 ident: CR13 article-title: A three-dimensional model of the human pulmonary acinus publication-title: J. Appl. Physiol. doi: 10.1152/jappl.2000.88.6.2260 – volume: 19 start-page: 1045 year: 2007 end-page: 1054 ident: CR26 article-title: Deposition of ultrafine (nano) particles in the human lung publication-title: Inhal. Toxicol. doi: 10.1080/08958370701626501 – volume: 6 start-page: e13709 year: 2018 ident: CR34 article-title: Modelling the effect of gravity on inert-gas washout outputs publication-title: Physiol. Rep. doi: 10.14814/phy2.13709 – volume: 120 start-page: 159 year: 2015 end-page: 165 ident: CR8 article-title: Experimental evidence of age-related adaptive changes in human acinar airways publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00541.2015 – volume: 3 start-page: 95 year: 1977 end-page: 102 ident: CR24 article-title: An experimental model and automated methodology for the analysis of the effects of ambient levels of air pollutants on the lung publication-title: Appl. Math. Comput. doi: 10.1016/0898-1221(77)90061-X – volume: 62 start-page: 25 year: 2015 end-page: 32 ident: CR11 article-title: Mathematical model of a heterogeneous pulmonary acinus structure publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2015.03.032 – volume: 37 start-page: 5591 year: 2013 end-page: 5605 ident: CR27 article-title: A fully Eulerian approach to particle inertial deposition in a physiologically realistic bifurcation publication-title: Appl. Math. Model. doi: 10.1016/j.apm.2012.10.055 – volume: 148 start-page: 3 year: 2005 end-page: 21 ident: CR33 article-title: Design of peripheral airways for efficient gas exchange publication-title: Respir. Physiol. Neurobiol. doi: 10.1016/j.resp.2005.03.005 – volume: 118 start-page: 267 year: 2001 ident: 1764_CR46 publication-title: J. Gen. Physiol. doi: 10.1085/jgp.118.3.267 – volume: 24 start-page: 182 year: 2012 ident: 1764_CR28 publication-title: Inhal. Toxicol. doi: 10.3109/08958378.2012.654857 – volume: 293 start-page: 1607 year: 2010 ident: 1764_CR6 publication-title: Anat. Rec. doi: 10.1002/ar.21161 – volume: 427 start-page: 633 year: 2004 ident: 1764_CR37 publication-title: Nature doi: 10.1038/nature02287 – volume: 134 start-page: 061001 year: 2012 ident: 1764_CR15 publication-title: J. Biomech. Eng. doi: 10.1115/1.4006809 – ident: 1764_CR25 – volume: 132 start-page: 1 year: 2016 ident: 1764_CR31 publication-title: Comput. Methods Programs Biomed. doi: 10.1016/j.cmpb.2016.04.021 – volume: 37 start-page: 5591 year: 2013 ident: 1764_CR27 publication-title: Appl. Math. Model. doi: 10.1016/j.apm.2012.10.055 – volume: 220 start-page: 401 year: 1988 ident: 1764_CR1 publication-title: Anat. Rec. doi: 10.1002/ar.1092200410 – volume: 19 start-page: 1045 year: 2007 ident: 1764_CR26 publication-title: Inhal. Toxicol. doi: 10.1080/08958370701626501 – volume: 38 start-page: 990 year: 1975 ident: 1764_CR4 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1975.38.6.990 – ident: 1764_CR29 doi: 10.1021/acs.iecr.0c05699 – volume: 87 start-page: 2207 year: 1999 ident: 1764_CR32 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1999.87.6.2207 – volume: 9 start-page: 387 year: 1970 ident: 1764_CR35 publication-title: Respir. Physiol. doi: 10.1016/0034-5687(70)90094-0 – volume: 275 start-page: 207 year: 2003 ident: 1764_CR20 publication-title: Anat. Rec. Part B New Anat. Off. Publ. Am. Assoc. Anat. doi: 10.1002/ar.b.10034 – volume: 6 start-page: e13709 year: 2018 ident: 1764_CR34 publication-title: Physiol. Rep. doi: 10.14814/phy2.13709 – volume: 136 start-page: 1 year: 2021 ident: 1764_CR2 publication-title: Eur. Phys. J. Plus doi: 10.1140/epjp/s13360-021-01175-8 – volume: 95 start-page: 168101 year: 2005 ident: 1764_CR18 publication-title: Phys. Rev. Lett. doi: 10.1103/PhysRevLett.95.168101 – volume: 32 start-page: 121 year: 1978 ident: 1764_CR39 publication-title: Respir. Physiol. doi: 10.1016/0034-5687(78)90104-4 – volume: 89 start-page: 1859 year: 2000 ident: 1764_CR19 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.2000.89.5.1859 – volume: 113 start-page: 53 year: 2018 ident: 1764_CR16 publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.09.033 – volume: 133 start-page: 99 year: 2002 ident: 1764_CR44 publication-title: Respir. Physiol. Neurobiol. doi: 10.1016/S1569-9048(02)00136-2 – volume: 88 start-page: 2260 year: 2000 ident: 1764_CR13 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.2000.88.6.2260 – volume: 31 start-page: 386 year: 1971 ident: 1764_CR40 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1971.31.3.386 – volume: 18 start-page: 280 year: 1968 ident: 1764_CR45 publication-title: J. Theor. Biol. doi: 10.1016/0022-5193(68)90079-9 – volume: 162 start-page: 221 year: 1981 ident: 1764_CR5 publication-title: Am. J. Anat. doi: 10.1002/aja.1001620304 – volume: 118 start-page: 1429 year: 2015 ident: 1764_CR38 publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.01017.2014 – volume: 196 start-page: 105613 year: 2020 ident: 1764_CR9 publication-title: Comput. Methods Programs Biomed. doi: 10.1016/j.cmpb.2020.105613 – volume: 127 start-page: 241 year: 2001 ident: 1764_CR10 publication-title: Respir. Physiol. doi: 10.1016/S0034-5687(01)00238-9 – volume: 131 start-page: 031010 year: 2009 ident: 1764_CR14 publication-title: J. Biomech. Eng. doi: 10.1115/1.3049481 – volume: 3 start-page: 95 year: 1977 ident: 1764_CR24 publication-title: Appl. Math. Comput. doi: 10.1016/0898-1221(77)90061-X – volume: 7 start-page: 79 year: 2004 ident: 1764_CR48 publication-title: Curr. Opin. Plant Biol. doi: 10.1016/j.pbi.2003.11.007 – volume: 38 start-page: 983 year: 1975 ident: 1764_CR3 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1975.38.6.983 – volume: 91 start-page: 58 year: 2021 ident: 1764_CR23 publication-title: Appl. Math. Model. doi: 10.1016/j.apm.2020.08.051 – volume-title: Morphometry of the Human Lung year: 1963 ident: 1764_CR21 doi: 10.1007/978-3-642-87553-3 – volume: 120 start-page: 159 year: 2015 ident: 1764_CR8 publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00541.2015 – volume: 93 start-page: 125 year: 1993 ident: 1764_CR36 publication-title: Respir. Physiol. doi: 10.1016/0034-5687(93)90001-Q – volume: 62 start-page: 25 year: 2015 ident: 1764_CR11 publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2015.03.032 – volume: 41 start-page: 507 year: 2013 ident: 1764_CR22 publication-title: Eur. Respir. J. doi: 10.1183/09031936.00069712 – volume: 148 start-page: 3 year: 2005 ident: 1764_CR33 publication-title: Respir. Physiol. Neurobiol. doi: 10.1016/j.resp.2005.03.005 – volume: 127 start-page: 249 year: 2001 ident: 1764_CR42 publication-title: Respir. Physiol. doi: 10.1016/S0034-5687(01)00239-0 – ident: 1764_CR47 doi: 10.1007/11795018_13 – volume: 107 start-page: 1258 year: 2009 ident: 1764_CR7 publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00386.2009 – volume: 59 start-page: 838 year: 1985 ident: 1764_CR43 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1985.59.3.838 – volume: 112 start-page: 937 year: 2011 ident: 1764_CR41 publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00768.2011 – volume: 113 start-page: 132 year: 2018 ident: 1764_CR17 publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.09.016 – volume-title: The Algorithmic Beauty of Plants year: 2012 ident: 1764_CR30 – volume: 222 start-page: 429 year: 2008 ident: 1764_CR12 publication-title: Proc. Inst. Mech. Eng. [H] doi: 10.1243/09544119JEIM309
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Snippet	Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model...
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SubjectTerms	Abnormalities Algorithms Alveoli Applied and Technical Physics Asymmetry Atomic Complex Systems Condensed Matter Physics Diameters Gas exchange Gases Low resistance Lungs Mathematical and Computational Physics Mechanical properties Molecular Nitrogen Optical and Plasma Physics Optimization Particle deposition Particle swarm optimization Physics Physics and Astronomy Physiology Rare gases Regular Article Theoretical Three dimensional models
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Title	Development of anatomically based structure for human acinus by Lindenmayer system: accurate model for gas exchange in human lung
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