The Effectiveness of Platelet-Rich Plasma as a Carrier of Stem Cells in Tissue Regeneration: A Systematic Review of Pre-Clinical Research
Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the ti...
Uloženo v:
| Vydáno v: | Cells, tissues, organs Ročník 210; číslo 5-6; s. 339 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Switzerland
01.12.2021
|
| Témata: | |
| ISSN: | 1422-6421, 1422-6421 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach. In this context, the aim of this narrative review is to compile the current evidence in vitro and in vivo regarding the combination of platelet-rich plasma (PRP) scaffolds and adult stem cells focusing on the regenerative medicine field according to the clinical application. A total of 1,832 articles were identified during the systematic literature search through three databases (Google Scholar, PubMed, and Web of Science). A total of 18 publications reaching the inclusion criteria were finally included in this review. According to the results, the combination of PRP and stem cells improved osteogenic and cartilage regeneration. However, regarding periodontal regeneration conflicting results were reported. Many other pathologies were also investigated, and even though no general conclusions were able to be obtained, most of them supported the superior performance of PRP-based scaffolds seeded with stem cells. Finally, the lack of a comprehensive description of the PRP composition makes it difficult to compare them and to draw robust conclusions. Therefore, an accurate and complete description of the product needs to be detailed in upcoming scientific publications. |
|---|---|
| AbstractList | Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach. In this context, the aim of this narrative review is to compile the current evidence in vitro and in vivo regarding the combination of platelet-rich plasma (PRP) scaffolds and adult stem cells focusing on the regenerative medicine field according to the clinical application. A total of 1,832 articles were identified during the systematic literature search through three databases (Google Scholar, PubMed, and Web of Science). A total of 18 publications reaching the inclusion criteria were finally included in this review. According to the results, the combination of PRP and stem cells improved osteogenic and cartilage regeneration. However, regarding periodontal regeneration conflicting results were reported. Many other pathologies were also investigated, and even though no general conclusions were able to be obtained, most of them supported the superior performance of PRP-based scaffolds seeded with stem cells. Finally, the lack of a comprehensive description of the PRP composition makes it difficult to compare them and to draw robust conclusions. Therefore, an accurate and complete description of the product needs to be detailed in upcoming scientific publications.Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach. In this context, the aim of this narrative review is to compile the current evidence in vitro and in vivo regarding the combination of platelet-rich plasma (PRP) scaffolds and adult stem cells focusing on the regenerative medicine field according to the clinical application. A total of 1,832 articles were identified during the systematic literature search through three databases (Google Scholar, PubMed, and Web of Science). A total of 18 publications reaching the inclusion criteria were finally included in this review. According to the results, the combination of PRP and stem cells improved osteogenic and cartilage regeneration. However, regarding periodontal regeneration conflicting results were reported. Many other pathologies were also investigated, and even though no general conclusions were able to be obtained, most of them supported the superior performance of PRP-based scaffolds seeded with stem cells. Finally, the lack of a comprehensive description of the PRP composition makes it difficult to compare them and to draw robust conclusions. Therefore, an accurate and complete description of the product needs to be detailed in upcoming scientific publications. Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach. In this context, the aim of this narrative review is to compile the current evidence in vitro and in vivo regarding the combination of platelet-rich plasma (PRP) scaffolds and adult stem cells focusing on the regenerative medicine field according to the clinical application. A total of 1,832 articles were identified during the systematic literature search through three databases (Google Scholar, PubMed, and Web of Science). A total of 18 publications reaching the inclusion criteria were finally included in this review. According to the results, the combination of PRP and stem cells improved osteogenic and cartilage regeneration. However, regarding periodontal regeneration conflicting results were reported. Many other pathologies were also investigated, and even though no general conclusions were able to be obtained, most of them supported the superior performance of PRP-based scaffolds seeded with stem cells. Finally, the lack of a comprehensive description of the PRP composition makes it difficult to compare them and to draw robust conclusions. Therefore, an accurate and complete description of the product needs to be detailed in upcoming scientific publications. |
| Author | Tierno, Roberto Anitua, Eduardo Alkhraisat, Mohammad H Troya, María Zalduendo, Mar |
| Author_xml | – sequence: 1 givenname: Eduardo surname: Anitua fullname: Anitua, Eduardo organization: BTI-Biotechnology Institute, Vitoria, Spain – sequence: 2 givenname: María surname: Troya fullname: Troya, María organization: BTI-Biotechnology Institute, Vitoria, Spain – sequence: 3 givenname: Roberto surname: Tierno fullname: Tierno, Roberto organization: BTI-Biotechnology Institute, Vitoria, Spain – sequence: 4 givenname: Mar surname: Zalduendo fullname: Zalduendo, Mar email: marimar.zalduendo@bti-implant.es organization: BTI-Biotechnology Institute, Vitoria, Spain, marimar.zalduendo@bti-implant.es – sequence: 5 givenname: Mohammad H surname: Alkhraisat fullname: Alkhraisat, Mohammad H organization: BTI-Biotechnology Institute, Vitoria, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34551408$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkNtKAzEQhoNU7EEvfAHJpTerOWx2G-_KUg9QUNp6vWSzExvZQ012K30E39pUKwgDM__Mxw__jNGgaRtA6JKSG0qFvCWECDqVMj5BIxozFiUxo4N_8xCNvX8PGAviDA15LASNyXSEvtYbwHNjQHd2Bw14j1uDXyrVQQVdtLR6c1C-Vlh5rHCmnLPgDtCqgxpnUFUe2wavrfc94CW8BRenOts2d3iGV3sfsCB1OO0sfP7YO4iyyjZWqyqsPSinN-fo1KjKw8WxT9Dr_XydPUaL54enbLaINOdxF7GUJYwZKYuC0LiUxmiujTKUJVwUCjST5ZSALAQDxlPNDQcaSipjytQUbIKuf323rv3owXd5bb0OMVQDbe9zJlIx5TwhMqBXR7QvaijzrbO1cvv8733sG5hZcwI |
| CitedBy_id | crossref_primary_10_1088_2053_1591_ad2160 crossref_primary_10_3390_dj11080184 crossref_primary_10_1177_03635465231168104 crossref_primary_10_1002_jrsm_1657 crossref_primary_10_3390_cimb47060445 crossref_primary_10_1177_19458924251369316 crossref_primary_10_3390_ijms23126552 crossref_primary_10_1016_j_ajoms_2024_02_009 crossref_primary_10_3390_ijms241713043 crossref_primary_10_1002_jbm_a_37579 crossref_primary_10_3390_jcm13010067 |
| ContentType | Journal Article |
| Copyright | 2021 S. Karger AG, Basel. |
| Copyright_xml | – notice: 2021 S. Karger AG, Basel. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1159/000518994 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Zoology Biology |
| EISSN | 1422-6421 |
| ExternalDocumentID | 34551408 |
| Genre | Research Support, Non-U.S. Gov't Systematic Review Journal Article |
| GroupedDBID | --- -~X .GJ 0R~ 0~5 0~B 29B 30W 326 34G 36B 39C 3O- 3O. 3V. 4.4 53G 5GY 6J9 7X7 88E 8AO 8FE 8FH 8FI 8FJ 8UI AAYIC ABBTS ABJNI ABPAZ ABUWG ABWCG ACGFS ACPRK ACPSR ADBBV ADFRT AENEX AEYAO AFJJK AFKRA AHFRZ AHMBA AI. ALDHI ALIPV ALMA_UNASSIGNED_HOLDINGS AZPMC BBNVY BENPR BHPHI BPHCQ BVXVI C45 CAG CCPQU CGR COF CS3 CUY CVF CYUIP DU5 E0A EBS ECM EIF EJD EMB EMOBN F5P FB. FYUFA HCIFZ HMCUK HZ~ IY7 KUZGX L7B LK8 M1P M7P N9A NPM O1H O9- OVD PQQKQ PROAC PSQYO RIG RKO RXVBD SV3 TEORI UJ6 UKHRP VH1 7X8 |
| ID | FETCH-LOGICAL-c334t-272622f99bb014d9ffc3cfaf12635baec29d80e9b52e237c3f3e13e19affd7fb2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 11 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000765982500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1422-6421 |
| IngestDate | Sun Nov 09 13:14:04 EST 2025 Wed Feb 19 02:27:59 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5-6 |
| Keywords | Fibrin stem cells PRGF Scaffolds Platelet-rich plasma |
| Language | English |
| License | 2021 S. Karger AG, Basel. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c334t-272622f99bb014d9ffc3cfaf12635baec29d80e9b52e237c3f3e13e19affd7fb2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| PMID | 34551408 |
| PQID | 2575833609 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2575833609 pubmed_primary_34551408 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-12-01 |
| PublicationDateYYYYMMDD | 2021-12-01 |
| PublicationDate_xml | – month: 12 year: 2021 text: 2021-12-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Cells, tissues, organs |
| PublicationTitleAlternate | Cells Tissues Organs |
| PublicationYear | 2021 |
| SSID | ssj0002421 |
| Score | 2.3748868 |
| SecondaryResourceType | review_article |
| Snippet | Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 339 |
| SubjectTerms | Fibrin Platelet-Rich Plasma Stem Cells Tissue Engineering Wound Healing |
| Title | The Effectiveness of Platelet-Rich Plasma as a Carrier of Stem Cells in Tissue Regeneration: A Systematic Review of Pre-Clinical Research |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34551408 https://www.proquest.com/docview/2575833609 |
| Volume | 210 |
| WOSCitedRecordID | wos000765982500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dS8MwEA9-44sf8_uLCL4GuyRbGl9EhuKDG8NNGb6MJE1EmK2uU_BP8L82l2b6JAhCKTS0peSul7vc3e-H0EmdCaab3BKVZpTwhhFEeqNIjOPGcK25DpQs9zei00kHA9mNG25lLKuc2sRgqLPCwB75qVctaBBqJvL85ZUAaxRkVyOFxiyaZ96VAa0Wgx-0cEh3hu4iH3BBQ2dEFvIreOCyq_tYg__uWYYV5mr1v9-2hlaib4kvKmVYRzM2r6HFim3yo4aW2jGP7gcfijC4gT69nuAKwjjaPVw43B15F9RLlEDfPVyVzwqrEivcUmPguIObehP7jFt2NCrxU477QYL41j4GIGuQ9xm-wL1vpGhcpSHC68eWREDSEZ7W_m2iu6vLfuuaRHoGYhjjE0IFbVLqpNTax1mZdM4w45SrA76NVtZQmaWJlbpBLWXCMMds3R9SOZcJp-kWmsuL3O4gLJrGpE6mmWUNLlyaZt5NkSIRCvJCSbaLjqcTP_TqDzkNldvirRz-TP0u2q6kN3ypcDqGjIM7mKR7f3h6Hy1TqFYJhSoHaN75n98eogXzPnkqx0dBr_y5021_AdU518k |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Effectiveness+of+Platelet-Rich+Plasma+as+a+Carrier+of+Stem+Cells+in+Tissue+Regeneration%3A+A+Systematic+Review+of+Pre-Clinical+Research&rft.jtitle=Cells%2C+tissues%2C+organs&rft.au=Anitua%2C+Eduardo&rft.au=Troya%2C+Mar%C3%ADa&rft.au=Tierno%2C+Roberto&rft.au=Zalduendo%2C+Mar&rft.date=2021-12-01&rft.issn=1422-6421&rft.eissn=1422-6421&rft.volume=210&rft.issue=5-6&rft.spage=339&rft_id=info:doi/10.1159%2F000518994&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-6421&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-6421&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-6421&client=summon |