Antimicrobial efficacy of 0·05% cetylpyridinium chloride mouthrinses

This study evaluated the antimicrobial activity of two commercially available 0·05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a cont...

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Vydáno v:Letters in applied microbiology Ročník 56; číslo 1; s. 14 - 20
Hlavní autoři: Sreenivasan, P.K., Haraszthy, V.I., Zambon, J.J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Oxford University Press 01.01.2013
Témata:
Adolescent
Adult
Aged
Anti-Bacterial Agents - pharmacology
antimicrobial susceptibility
Bacteria
Bacteria - classification
Bacteria - drug effects
Biofilms
Biofilms - drug effects
Cetylpyridinium - pharmacology
cetylpyridinium chloride
chlorhexidine
Chlorhexidine - pharmacology
dental plaque
Dental Plaque - microbiology
Ethanol - pharmacology
Fluorides - pharmacology
Humans
Microbial Sensitivity Tests
Middle Aged
mouthrinse
Mouthwashes - pharmacology
oral microbiology
Young Adult
ISSN:0266-8254, 1472-765X, 1472-765X
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Shrnutí:This study evaluated the antimicrobial activity of two commercially available 0·05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a control fluoride mouthrinse without CPC. Two different approaches were used to evaluate antimicrobial activity. First, the minimum inhibitory concentration (MIC) was determined for each mouthrinse against a panel of 25 micro‐organisms including species associated with dental caries, gingivitis and periodontitis. Second, supragingival dental plaque obtained from 15 adults was incubated with the four mouthrinses to evaluate antimicrobial activity on micro‐organisms in oral biofilms. Both CPC mouthrinses exhibited lower MIC's, that is, greater antimicrobial activity, against oral Gram‐negative bacteria especially periodontal pathogens and species implicated in halitosis such as Aggregatibacter actinomycemcomitans, Campylobacter rectus, Eikenella corrodens, Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei than the control mouthrinse. Ex‐vivo tests on supragingival plaque micro‐organisms demonstrated significantly greater antimicrobial activity by the CPC mouthrinses (>90% killing, P < 0·001) and the chlorhexidine rinse (>98% killing, P < 0·05) compared to the control fluoride mouthrinse. Whilst the chlorhexidine mouthrinse was most effective, mouthrinses containing 0·05% CPC formulated with or without alcohol demonstrated broad‐spectrum antimicrobial activity against both laboratory strains and supragingival plaque bacteria compared to a control mouthrinse without CPC. Significance and Impact of Study These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis. Significance and Impact of Study: These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.
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ISSN:0266-8254
1472-765X
1472-765X
DOI:10.1111/lam.12008