Technoeconomic Mixed Integer Nonlinear Programming (MINLP) optimization for design of Liquid‐Liquid Extraction (LLE) cascades in continuous pharmaceutical manufacturing of atropine

Continuous Pharmaceutical Manufacturing (CPM) offers operational and economic benefits over the currently dominant methods implemented by industry. The demonstrated continuous flow synthesis of atropine facilitates modeling and optimization of its upstream continuous manufacturing. This study implem...

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Veröffentlicht in:	AIChE journal Jg. 65; H. 11
Hauptverfasser:	Diab, Samir, Gerogiorgis, Dimitrios I.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 01.11.2019 American Institute of Chemical Engineers
Schlagworte:	Atropine Cascade flow Configuration management Continuous flow Design optimization Design parameters Liquid-liquid equilibrium Manufacturing Mass transfer Mixed integer Modelling Nonlinear programming Optimization Pharmaceuticals Reactor design Reactors Solvents Superstructures Synthesis Toluene Upstream
ISSN:	0001-1541, 1547-5905
Online-Zugang:	Volltext
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