Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics

Background It is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy (DSP), because some genes are involved in specific biological pathways, acting in different ways in the pathogenic process. Objective To ide...

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Published in:Arquivos de neuro-psiquiatria Vol. 82; no. 12; pp. 1 - 9
Main Authors: Silva, Raquel Garcia Rocco da, Lima, Marcelo A. Costa, Moura, Claudia de Melo, Luescher, Jorge Luiz, Campos, Ludmila Nascimento Rodrigues, Silva, Daniel de Souza e, Ribeiro, Márcia Gonçalves
Format: Journal Article
Language:English
Published: Germany Thieme Revinter Publicações Ltda 01.12.2024
Academia Brasileira de Neurologia - ABNEURO
Thieme Revinter Publicações
Series:December
Subjects:
Adolescent
Adolescente
Child
Criança
Diabetes Mellitus, Type 1 - genetics
Diabetic Neuropathies
Diabetic Neuropathies - genetics
Female
Genetic Predisposition to Disease - genetics
Genotype
Humans
Interleucina-4
Interleukin-4
Interleukin-4 - genetics
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Metilenotetra-hidrofolato Redutase (NADPH2)
Neural Conduction - genetics
Neural Conduction - physiology
Neuropatias Diabéticas
NEUROSCIENCES
Original
Polimorfismo Genético
Polymorphism, Genetic
Polymorphism, Genetic - genetics
PSYCHIATRY
Interleukin-4
Metilenotetra-hidrofolato Redutase (NADPH2)
Polimorfismo Genético
Interleucina-4
Adolescent
Methylenetetrahydrofolate Reductase (NADPH2)
Child
Neuropatias Diabéticas
Diabetic Neuropathies
Criança
Adolescente
Polymorphism, Genetic
ISSN:0004-282X, 1678-4227, 1678-4227
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Summary:Background It is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy (DSP), because some genes are involved in specific biological pathways, acting in different ways in the pathogenic process. Objective To identify potential associations involving the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and interleukin 4 (IL-4 intron 3 variable number of tandem repeats [I3VNTR]) gene polymorphisms and DSP in the studied sample. Methods In total, 70 children and adolescents with type-1 diabetes underwent a nerve conduction studie (NCS) of the sural nerve. Saliva samples were collected for DNA extraction and genotyping of the MTHFR C677T and IL-4 I3VNTR polymorphisms. Results The prevalence of DSP was 15.71%. The participants with DSP presented higher mean levels of glycated hemoglobin, triglycerides, total cholesterol, and low-density lipoprotein (LDL) (p > 0.05). The NCS amplitudes were lower in individuals with DSP (p = 0.00). The mean conduction velocity was lower in people with the A1A1 genotype (p = 0.02). Maternal and paternal history of diabetes in great-grandparents were associated with DSP (p = 0.04 and 0.02, respectively). Glycated hemoglobin and impaired Achilles reflex were associated with the MTHFR CC genotype (p = 0.04 and 0.05 respectively) and high-density lipoprotein (HDL) cholesterol was associated with the MTHFR CT genotype (p = 0.05). We found no association between the polymorphisms investigated and DSP. Conclusion In the present study, we found no association involving the MTHFR C677T and IL-4 I3VNTR polymorphisms and DSP. However, the study provides other associations and suggests possible implications for these findings.
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content type line 23
ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1055/s-0044-1793931