T Cell factor 1 represses CD8+ effector T cell formation and function

The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thymic T cell development and the formation of memory CD8(+) T cells. However, its role in the initial phases of CD8(+) T effector cell formation has remained unexplored. We report that high levels of Wnt si...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 193; no. 11; p. 5480
Main Authors:	Tiemessen, Machteld M, Baert, Miranda R M, Kok, Lianne, van Eggermond, Marja C J A, van den Elsen, Peter J, Arens, Ramon, Staal, Frank J T
Format:	Journal Article
Language:	English
Published:	United States 01.12.2014
Subjects:	Animals CD8-Positive T-Lymphocytes - immunology Cells, Cultured Cytotoxicity, Immunologic DNA Methylation Gene Dosage Hepatocyte Nuclear Factor 1-alpha - genetics Hepatocyte Nuclear Factor 1-alpha - metabolism Immunologic Memory Interferon-gamma - genetics Interferon-gamma - metabolism Lymphocytic Choriomeningitis - immunology Lymphocytic choriomeningitis virus - immunology Mice Mice, Inbred C57BL Mice, Knockout Positive Regulatory Domain I-Binding Factor 1 Protein Stability Repressor Proteins - genetics Repressor Proteins - metabolism T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Up-Regulation Viral Load Virus Diseases
ISSN:	1550-6606, 1550-6606
Online Access:	Get more information
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