Factor v Leiden mutation in severe infection and sepsis

In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis....

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Vydáno v:Seminars in thrombosis and hemostasis Ročník 37; číslo 8; s. 955
Hlavní autoři: Levi, Marcel, Schouten, Marcel, van't Veer, Cees, van der Poll, Tom
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.11.2011
Témata:
Animals
Factor V - genetics
Humans
Infection - blood
Infection - genetics
Mice
Mutation
Sepsis - blood
Sepsis - genetics
Thrombophilia - blood
Thrombophilia - genetics
Thrombophilia - microbiology
ISSN:1098-9064, 1098-9064
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Shrnutí:In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1098-9064
1098-9064
DOI:10.1055/s-0031-1297374