Factor v Leiden mutation in severe infection and sepsis

In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis....

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Published in:Seminars in thrombosis and hemostasis Vol. 37; no. 8; p. 955
Main Authors: Levi, Marcel, Schouten, Marcel, van't Veer, Cees, van der Poll, Tom
Format: Journal Article
Language:English
Published: United States 01.11.2011
Subjects:
Animals
Factor V - genetics
Humans
Infection - blood
Infection - genetics
Mice
Mutation
Sepsis - blood
Sepsis - genetics
Thrombophilia - blood
Thrombophilia - genetics
Thrombophilia - microbiology
ISSN:1098-9064, 1098-9064
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Abstract In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
AbstractList In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
Author van't Veer, Cees
Schouten, Marcel
van der Poll, Tom
Levi, Marcel
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  organization: Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.m.levi@amc.uva.nl
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  fullname: van der Poll, Tom
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22198860$$D View this record in MEDLINE/PubMed
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SubjectTerms Animals
Factor V - genetics
Humans
Infection - blood
Infection - genetics
Mice
Mutation
Sepsis - blood
Sepsis - genetics
Thrombophilia - blood
Thrombophilia - genetics
Thrombophilia - microbiology
Title Factor v Leiden mutation in severe infection and sepsis
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