NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin

NK cells play a major role in protection against tumor recurrence and infection after allogeneic hematopoietic stem cell transplantation (HSCT). It has been shown that NK cell function after HSCT is impaired, but underlying molecular mechanisms are not well-known. In this report we show that the lev...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 195; no. 10; p. 4712
Main Authors:	Simonetta, Federico, Pradier, Amandine, Bosshard, Carine, Masouridi-Levrat, Stavroula, Chalandon, Yves, Roosnek, Eddy
Format:	Journal Article
Language:	English
Published:	United States 15.11.2015
Subjects:	Adolescent Adult Aged CD56 Antigen - biosynthesis Female Graft vs Host Disease - immunology Hematopoietic Stem Cell Transplantation Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Male Middle Aged Perforin - biosynthesis T-Box Domain Proteins - biosynthesis T-Box Domain Proteins - metabolism Transcription, Genetic Transplantation, Homologous Young Adult
ISSN:	1550-6606, 1550-6606
Online Access:	Get more information
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