Humoral regulation of heart rate during digestion in pythons (Python molurus and Python regius)
Pythons exhibit a doubling of heart rate when metabolism increases several times during digestion. Pythons, therefore, represent a promising model organism to study autonomic cardiovascular regulation during the postprandial state, and previous studies show that the postprandial tachycardia is gover...
Uloženo v:
| Vydáno v: | American journal of physiology. Regulatory, integrative and comparative physiology Ročník 302; číslo 10; s. R1176 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
15.05.2012
|
| Témata: | |
| ISSN: | 1522-1490, 1522-1490 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Pythons exhibit a doubling of heart rate when metabolism increases several times during digestion. Pythons, therefore, represent a promising model organism to study autonomic cardiovascular regulation during the postprandial state, and previous studies show that the postprandial tachycardia is governed by a release of vagal tone as well as a pronounced stimulation from nonadrenergic, noncholinergic (NANC) factors. Here we show that infusion of plasma from digesting donor pythons elicit a marked tachycardia in fasting snakes, demonstrating that the NANC factor resides in the blood. Injections of the gastrin and cholecystokinin receptor antagonist proglumide had no effect on double-blocked heart rate or blood pressure. Histamine has been recognized as a NANC factor in the early postprandial period in pythons, but the mechanism of its release has not been identified. Mast cells represent the largest repository of histamine in vertebrates, and it has been speculated that mast cells release histamine during digestion. Treatment with the mast cell stabilizer cromolyn significantly reduced postprandial heart rate in pythons compared with an untreated group but did not affect double-blocked heart rate. While this study indicates that histamine induces postprandial tachycardia in pythons, its release during digestion is not stimulated by gastrin or cholecystokinin nor is its release from mast cells a stimulant of postprandial tachycardia. |
|---|---|
| AbstractList | Pythons exhibit a doubling of heart rate when metabolism increases several times during digestion. Pythons, therefore, represent a promising model organism to study autonomic cardiovascular regulation during the postprandial state, and previous studies show that the postprandial tachycardia is governed by a release of vagal tone as well as a pronounced stimulation from nonadrenergic, noncholinergic (NANC) factors. Here we show that infusion of plasma from digesting donor pythons elicit a marked tachycardia in fasting snakes, demonstrating that the NANC factor resides in the blood. Injections of the gastrin and cholecystokinin receptor antagonist proglumide had no effect on double-blocked heart rate or blood pressure. Histamine has been recognized as a NANC factor in the early postprandial period in pythons, but the mechanism of its release has not been identified. Mast cells represent the largest repository of histamine in vertebrates, and it has been speculated that mast cells release histamine during digestion. Treatment with the mast cell stabilizer cromolyn significantly reduced postprandial heart rate in pythons compared with an untreated group but did not affect double-blocked heart rate. While this study indicates that histamine induces postprandial tachycardia in pythons, its release during digestion is not stimulated by gastrin or cholecystokinin nor is its release from mast cells a stimulant of postprandial tachycardia.Pythons exhibit a doubling of heart rate when metabolism increases several times during digestion. Pythons, therefore, represent a promising model organism to study autonomic cardiovascular regulation during the postprandial state, and previous studies show that the postprandial tachycardia is governed by a release of vagal tone as well as a pronounced stimulation from nonadrenergic, noncholinergic (NANC) factors. Here we show that infusion of plasma from digesting donor pythons elicit a marked tachycardia in fasting snakes, demonstrating that the NANC factor resides in the blood. Injections of the gastrin and cholecystokinin receptor antagonist proglumide had no effect on double-blocked heart rate or blood pressure. Histamine has been recognized as a NANC factor in the early postprandial period in pythons, but the mechanism of its release has not been identified. Mast cells represent the largest repository of histamine in vertebrates, and it has been speculated that mast cells release histamine during digestion. Treatment with the mast cell stabilizer cromolyn significantly reduced postprandial heart rate in pythons compared with an untreated group but did not affect double-blocked heart rate. While this study indicates that histamine induces postprandial tachycardia in pythons, its release during digestion is not stimulated by gastrin or cholecystokinin nor is its release from mast cells a stimulant of postprandial tachycardia. Pythons exhibit a doubling of heart rate when metabolism increases several times during digestion. Pythons, therefore, represent a promising model organism to study autonomic cardiovascular regulation during the postprandial state, and previous studies show that the postprandial tachycardia is governed by a release of vagal tone as well as a pronounced stimulation from nonadrenergic, noncholinergic (NANC) factors. Here we show that infusion of plasma from digesting donor pythons elicit a marked tachycardia in fasting snakes, demonstrating that the NANC factor resides in the blood. Injections of the gastrin and cholecystokinin receptor antagonist proglumide had no effect on double-blocked heart rate or blood pressure. Histamine has been recognized as a NANC factor in the early postprandial period in pythons, but the mechanism of its release has not been identified. Mast cells represent the largest repository of histamine in vertebrates, and it has been speculated that mast cells release histamine during digestion. Treatment with the mast cell stabilizer cromolyn significantly reduced postprandial heart rate in pythons compared with an untreated group but did not affect double-blocked heart rate. While this study indicates that histamine induces postprandial tachycardia in pythons, its release during digestion is not stimulated by gastrin or cholecystokinin nor is its release from mast cells a stimulant of postprandial tachycardia. |
| Author | Wang, Tobias Pedersen, Signe Vesterskov Skovgaard, Nini Simonsen, Lasse Stærdal Enok, Sanne |
| Author_xml | – sequence: 1 givenname: Sanne surname: Enok fullname: Enok, Sanne organization: Zoophysiology, Department of Bioscience, Aarhus University, Denmark – sequence: 2 givenname: Lasse Stærdal surname: Simonsen fullname: Simonsen, Lasse Stærdal – sequence: 3 givenname: Signe Vesterskov surname: Pedersen fullname: Pedersen, Signe Vesterskov – sequence: 4 givenname: Tobias surname: Wang fullname: Wang, Tobias – sequence: 5 givenname: Nini surname: Skovgaard fullname: Skovgaard, Nini |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22422667$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkM1OwzAQhC1URH_gBTggH8shxWu7TntEVaFIleAA52iTOK2rxA52fOjbk5YicdrRzqfRaMZkYJ3VhNwDmwHM-RMeWq93ccaYUjDjDOCKjHqDJyCXbPBPD8k4hANjTAopbsiQc8m5UumIZJvYOI81PSXV2BlnqavoXqPvqMdO0zJ6Y3e0NDsdzraxtD12e2cDnX6cBW1cHX0MFG1JL68-z8TweEuuK6yDvrvcCfl6WX-uNsn2_fVt9bxNCiGgS4ReFFwUYiFVmVYo2bxgaS4BZA5MiwpBcejLF6WacwDMtUyXxYlJNWKu-IRMf3Nb775j3zRrTCh0XaPVLoYMGEjggino0YcLGvNGl1nrTYP-mP2Nwn8ATGxniw |
| CitedBy_id | crossref_primary_10_1007_s00360_013_0746_3 crossref_primary_10_1242_jeb_197848 crossref_primary_10_1016_j_cbpa_2014_12_031 crossref_primary_10_1073_pnas_2322726121 crossref_primary_10_1242_jeb_248021 crossref_primary_10_1002_jez_2036 crossref_primary_10_1111_apha_12170 crossref_primary_10_1111_vaa_12321 crossref_primary_10_1007_s00360_020_01338_6 crossref_primary_10_1016_j_biopsycho_2022_108382 crossref_primary_10_1093_gigascience_gix057 crossref_primary_10_1007_s10974_022_09632_2 crossref_primary_10_1016_j_cbpa_2017_02_012 crossref_primary_10_1242_jeb_160549 crossref_primary_10_1242_jeb_177766 crossref_primary_10_1242_jeb_142729 crossref_primary_10_1093_conphys_coaf042 crossref_primary_10_1242_jeb_247445 crossref_primary_10_1242_jeb_242202 crossref_primary_10_1242_jeb_247105 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1152/ajpregu.00661.2011 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1522-1490 |
| ExternalDocumentID | 22422667 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | 23M 2WC 39C 4.4 5GY 5VS 6J9 AAFWJ ACIWK ACPRK ADBBV AFRAH ALMA_UNASSIGNED_HOLDINGS BAWUL BKKCC BKOMP BTFSW C1A CGR CUY CVF EBS ECM EIF EJD EMOBN F5P H13 ITBOX KQ8 NPM OK1 P2P PQQKQ RAP RHI RPL RPRKH TR2 UKR W8F WH7 WOQ XSW YSK ~02 7X8 |
| ID | FETCH-LOGICAL-c331t-3e8c23c3846d7fa405c07b4114b10e3fa1621434cd65211abe479cc07b7eaab62 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 37 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000304349400006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1522-1490 |
| IngestDate | Sun Nov 09 12:27:54 EST 2025 Thu Apr 03 06:58:46 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c331t-3e8c23c3846d7fa405c07b4114b10e3fa1621434cd65211abe479cc07b7eaab62 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 22422667 |
| PQID | 1014123061 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1014123061 pubmed_primary_22422667 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-05-15 |
| PublicationDateYYYYMMDD | 2012-05-15 |
| PublicationDate_xml | – month: 05 year: 2012 text: 2012-05-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | American journal of physiology. Regulatory, integrative and comparative physiology |
| PublicationTitleAlternate | Am J Physiol Regul Integr Comp Physiol |
| PublicationYear | 2012 |
| SSID | ssj0004343 |
| Score | 2.2214162 |
| Snippet | Pythons exhibit a doubling of heart rate when metabolism increases several times during digestion. Pythons, therefore, represent a promising model organism to... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | R1176 |
| SubjectTerms | Animals Blood Pressure - drug effects Blood Pressure - physiology Boidae - physiology Cromolyn Sodium - pharmacology Digestion - physiology Gastrins - antagonists & inhibitors Gastrins - drug effects Heart Rate - physiology Histamine - metabolism Histamine Antagonists - pharmacology Mast Cells - drug effects Mast Cells - metabolism Models, Animal Postprandial Period - physiology Proglumide - pharmacology Receptors, Cholecystokinin - antagonists & inhibitors Receptors, Cholecystokinin - drug effects Tachycardia - physiopathology |
| Title | Humoral regulation of heart rate during digestion in pythons (Python molurus and Python regius) |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22422667 https://www.proquest.com/docview/1014123061 |
| Volume | 302 |
| WOSCitedRecordID | wos000304349400006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JS8NAFB7UevDiVpe6MYKIHgY7mTSTnKSIxYOWHlR6C7NFKjSNTSv03_veJEUvguAlhCwQ5r28-d76EXIR48wsFzvWMaFlodKGJYkSTHPLTVubMPbt0a-Pst-Ph8NkUAfcyrqscmkTvaG2E4Mx8hvklOWIl_lt8cGQNQqzqzWFxippCIAyWNIlhz-mhYuqwB4wBgNPoL1smukEN-q9mLq3OZZ1RdxP8vwdYvqtprf134_cJps1yKTdSit2yIrLd0mzm4ODPV7QS-rLPn08vUlSECh26dNpxUoPcqKTjCLR9YziHAladTJS61NReHuU02KBMwdKejXwJ3QMGjydl1TlltaXkPJhXl7vkZfe_fPdA6tZF5gRgs-YcLEJhBEATKzMFAA605Y6BL9J87YTmeJRACArNDaCrZ8r7UKZGHxGOqV0FOyTtXySu0NC4ySyGgyYi5wOVWwT6YLMSRs7K2QnClvkfLmMKWg1pipU7ibzMv1eyBY5qGSRFtX4jRRAB2DGSB794e1jsgGyDTDdzzsnpJHBP-1Oybr5nI3K6ZlXFzj2B09f6DDLYw |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Humoral+regulation+of+heart+rate+during+digestion+in+pythons+%28Python+molurus+and+Python+regius%29&rft.jtitle=American+journal+of+physiology.+Regulatory%2C+integrative+and+comparative+physiology&rft.au=Enok%2C+Sanne&rft.au=Simonsen%2C+Lasse+St%C3%A6rdal&rft.au=Pedersen%2C+Signe+Vesterskov&rft.au=Wang%2C+Tobias&rft.date=2012-05-15&rft.eissn=1522-1490&rft.volume=302&rft.issue=10&rft.spage=R1176&rft_id=info:doi/10.1152%2Fajpregu.00661.2011&rft_id=info%3Apmid%2F22422667&rft_id=info%3Apmid%2F22422667&rft.externalDocID=22422667 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1522-1490&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1522-1490&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1522-1490&client=summon |