Box–Behnken design aided optimization and validation of developed reverse phase HPLC analytical method for simultaneous quantification of dolutegravir sodium and lamivudine co‐loaded in nano‐liposomes

A stability‐indicating reversed‐phase high‐performance liquid chromatography method for simultaneous estimation of dolutegravir sodium and lamivudine encapsulated in the nanoliposomal formulation was developed. The chromatographic parameters namely, organic phase ratio, flow rate, and sample injecti...

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Bibliographic Details
Published in:	Journal of separation science Vol. 44; no. 15; pp. 2917 - 2931
Main Authors:	Mutalik, Sadhana P, Mullick, Prashansha, Pandey, Abhijeet, Kulkarni, Smita S., Mutalik, Srinivas
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01.08.2021
Subjects:	Acetonitrile Acidification Antiretroviral drugs Box–Behnken design Chromatography Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase - methods Design optimization dolutegravir Drug Carriers Drug Compounding drugs experimental design Flow velocity Heterocyclic Compounds, 3-Ring - analysis High-performance liquid chromatography HIV Integrase Inhibitors - analysis Ions lamivudine Lamivudine - analysis Limit of Detection Liposomes liquid chromatography Mathematical analysis methanol Nanoparticles nano‐liposomes Oxazines - analysis Parameters Phase ratio phosphoric acid Piperazines - analysis Pyridones - analysis Reverse Transcriptase Inhibitors - analysis reversed-phase high performance liquid chromatography separation Sodium liquid chromatography nano-liposomes dolutegravir Box-Behnken design lamivudine
ISSN:	1615-9306, 1615-9314, 1615-9314
Online Access:	Get full text
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