The complex role of MEG3: An emerging long non-coding RNA in breast cancer
MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse biological processes, particularly breast cancer (BC) development. Within the imprinting DLK-MEG3 region on human chromosomal region 14q32.3, MEG3 spans 35 kb and encompasses ten exons. It exerts regulatory effects...
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| Published in: | Pathology, research and practice Vol. 251; p. 154850 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01.11.2023
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| ISSN: | 0344-0338, 1618-0631, 1618-0631 |
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| Abstract | MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse biological processes, particularly breast cancer (BC) development. Within the imprinting DLK-MEG3 region on human chromosomal region 14q32.3, MEG3 spans 35 kb and encompasses ten exons. It exerts regulatory effects through intricate interactions with miRNAs, proteins, and epigenetic modifications. MEG3's multifaceted function in BC is evident in gene expression modulation, osteogenic tissue differentiation, and involvement in bone-related conditions. Its role as a tumor suppressor is highlighted by its influence on miR-182 and miRNA-29 expression in BC. Additionally, MEG3 is implicated in acute myocardial infarction and endothelial cell function, emphasising cell-specific regulatory mechanisms. MEG3's impact on gene activity encompasses transcriptional and post-translational adjustments, including DNA methylation, histone modifications, and interactions with transcription factors. MEG3 dysregulation is linked to unfavourable outcomes and drug resistance. Notably, higher MEG3 expression is associated with enhanced survival in BC patients. Overcoming challenges such as unravelling context-specific interactions, understanding epigenetic control, and translating findings into clinical applications is imperative. Prospective endeavours involve elucidating underlying mechanisms, exploring epigenetic alterations, and advancing MEG3-based diagnostic and therapeutic approaches. A comprehensive investigation into broader signaling networks and rigorous clinical trials are pivotal. Rigorous validation through functional and molecular analyses will shed light on MEG3's intricate contribution to BC progression. |
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| AbstractList | MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse biological processes, particularly breast cancer (BC) development. Within the imprinting DLK-MEG3 region on human chromosomal region 14q32.3, MEG3 spans 35 kb and encompasses ten exons. It exerts regulatory effects through intricate interactions with miRNAs, proteins, and epigenetic modifications. MEG3's multifaceted function in BC is evident in gene expression modulation, osteogenic tissue differentiation, and involvement in bone-related conditions. Its role as a tumor suppressor is highlighted by its influence on miR-182 and miRNA-29 expression in BC. Additionally, MEG3 is implicated in acute myocardial infarction and endothelial cell function, emphasising cell-specific regulatory mechanisms. MEG3's impact on gene activity encompasses transcriptional and post-translational adjustments, including DNA methylation, histone modifications, and interactions with transcription factors. MEG3 dysregulation is linked to unfavourable outcomes and drug resistance. Notably, higher MEG3 expression is associated with enhanced survival in BC patients. Overcoming challenges such as unravelling context-specific interactions, understanding epigenetic control, and translating findings into clinical applications is imperative. Prospective endeavours involve elucidating underlying mechanisms, exploring epigenetic alterations, and advancing MEG3-based diagnostic and therapeutic approaches. A comprehensive investigation into broader signaling networks and rigorous clinical trials are pivotal. Rigorous validation through functional and molecular analyses will shed light on MEG3's intricate contribution to BC progression.MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse biological processes, particularly breast cancer (BC) development. Within the imprinting DLK-MEG3 region on human chromosomal region 14q32.3, MEG3 spans 35 kb and encompasses ten exons. It exerts regulatory effects through intricate interactions with miRNAs, proteins, and epigenetic modifications. MEG3's multifaceted function in BC is evident in gene expression modulation, osteogenic tissue differentiation, and involvement in bone-related conditions. Its role as a tumor suppressor is highlighted by its influence on miR-182 and miRNA-29 expression in BC. Additionally, MEG3 is implicated in acute myocardial infarction and endothelial cell function, emphasising cell-specific regulatory mechanisms. MEG3's impact on gene activity encompasses transcriptional and post-translational adjustments, including DNA methylation, histone modifications, and interactions with transcription factors. MEG3 dysregulation is linked to unfavourable outcomes and drug resistance. Notably, higher MEG3 expression is associated with enhanced survival in BC patients. Overcoming challenges such as unravelling context-specific interactions, understanding epigenetic control, and translating findings into clinical applications is imperative. Prospective endeavours involve elucidating underlying mechanisms, exploring epigenetic alterations, and advancing MEG3-based diagnostic and therapeutic approaches. A comprehensive investigation into broader signaling networks and rigorous clinical trials are pivotal. Rigorous validation through functional and molecular analyses will shed light on MEG3's intricate contribution to BC progression. MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse biological processes, particularly breast cancer (BC) development. Within the imprinting DLK-MEG3 region on human chromosomal region 14q32.3, MEG3 spans 35 kb and encompasses ten exons. It exerts regulatory effects through intricate interactions with miRNAs, proteins, and epigenetic modifications. MEG3's multifaceted function in BC is evident in gene expression modulation, osteogenic tissue differentiation, and involvement in bone-related conditions. Its role as a tumor suppressor is highlighted by its influence on miR-182 and miRNA-29 expression in BC. Additionally, MEG3 is implicated in acute myocardial infarction and endothelial cell function, emphasising cell-specific regulatory mechanisms. MEG3's impact on gene activity encompasses transcriptional and post-translational adjustments, including DNA methylation, histone modifications, and interactions with transcription factors. MEG3 dysregulation is linked to unfavourable outcomes and drug resistance. Notably, higher MEG3 expression is associated with enhanced survival in BC patients. Overcoming challenges such as unravelling context-specific interactions, understanding epigenetic control, and translating findings into clinical applications is imperative. Prospective endeavours involve elucidating underlying mechanisms, exploring epigenetic alterations, and advancing MEG3-based diagnostic and therapeutic approaches. A comprehensive investigation into broader signaling networks and rigorous clinical trials are pivotal. Rigorous validation through functional and molecular analyses will shed light on MEG3's intricate contribution to BC progression. |
| ArticleNumber | 154850 |
| Author | Khan, Ruqaiyah Bin Break, Mohammed Khaled Syed, Rahamat Unissa Altwaijry, Najla Khalifa, Nasrin E. Ali, Haider Almalki, Waleed Hassan Kazmi, Imran Gupta, Gaurav Alzarea, Sami I. Sharma, Rahul Hussain, Md Sadique Majami, Abdullah A. |
| Author_xml | – sequence: 1 givenname: Md Sadique surname: Hussain fullname: Hussain, Md Sadique organization: School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, Rajasthan, India – sequence: 2 givenname: Abdullah A. surname: Majami fullname: Majami, Abdullah A. organization: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia – sequence: 3 givenname: Haider surname: Ali fullname: Ali, Haider email: haiderali.pharma@hotmail.com, alicim01@gmail.com organization: Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan – sequence: 4 givenname: Gaurav surname: Gupta fullname: Gupta, Gaurav organization: Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India – sequence: 5 givenname: Waleed Hassan surname: Almalki fullname: Almalki, Waleed Hassan organization: Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia – sequence: 6 givenname: Sami I. surname: Alzarea fullname: Alzarea, Sami I. organization: Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia – sequence: 7 givenname: Imran surname: Kazmi fullname: Kazmi, Imran organization: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia – sequence: 8 givenname: Rahamat Unissa surname: Syed fullname: Syed, Rahamat Unissa organization: Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia – sequence: 9 givenname: Nasrin E. surname: Khalifa fullname: Khalifa, Nasrin E. organization: Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia – sequence: 10 givenname: Mohammed Khaled surname: Bin Break fullname: Bin Break, Mohammed Khaled organization: Medical and Diagnostic Research Centre, University of Hail, Hail 55473, Saudi Arabia – sequence: 11 givenname: Ruqaiyah surname: Khan fullname: Khan, Ruqaiyah organization: Department of Basic Health Sciences, Deanship of Preparatory Year for the Health Colleges, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia – sequence: 12 givenname: Najla surname: Altwaijry fullname: Altwaijry, Najla organization: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint, Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia – sequence: 13 givenname: Rahul surname: Sharma fullname: Sharma, Rahul organization: School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, Rajasthan, India |
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| Copyright | 2023 Elsevier GmbH Copyright © 2023 Elsevier GmbH. All rights reserved. |
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