Porphyromonas gingivalis survival skills: Immune evasion

Periodontitis is a chronic inflammatory condition that destroys the tooth‐supporting tissues and eventually leads to tooth loss. As one of the most prevalent oral conditions, periodontitis endangers the oral health of 70% of people throughout the world. Periodontitis is also related to various syste...

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Veröffentlicht in:Journal of periodontal research Jg. 56; H. 6; S. 1007 - 1018
Hauptverfasser: Zheng, Shaowen, Yu, Shiwen, Fan, Xiaomiao, Zhang, Yonghuan, Sun, Yangyang, Lin, Li, Wang, Hongyan, Pan, Yaping, Li, Chen
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Hoboken Wiley Subscription Services, Inc 01.12.2021
Schlagworte:
Adaptive immunity
Arteriosclerosis
Autophagy
Biodegradation
Complement system
Diabetes mellitus
Epithelial cells
Gum disease
immune escape
Immune evasion
Inflammation
innate immunity
Periodontitis
Phagocytosis
Porphyromonas gingivalis
Quality of life
Rheumatoid arthritis
Systemic diseases
Virulence factors
ISSN:0022-3484, 1600-0765, 1600-0765
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Zusammenfassung:Periodontitis is a chronic inflammatory condition that destroys the tooth‐supporting tissues and eventually leads to tooth loss. As one of the most prevalent oral conditions, periodontitis endangers the oral health of 70% of people throughout the world. Periodontitis is also related to various systemic diseases, such as diabetes mellitus, atherosclerosis, and rheumatoid arthritis, which not only has a great impact on population health status and the quality of life but also increases the social burden. Porphyromonas gingivalis (P. gingivalis) is a gram‐negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. Porphyromonas gingivalis can express various of virulence factors to overturn innate and adaptive immunities, which makes P. gingivalis survive and propagate in the host, destroy periodontal tissues, and have connection to systemic diseases. Porphyromonas gingivalis can invade into and survive in host tissues by destructing the gingival epithelial barrier, internalizing into the epithelial cells, and enhancing autophagy in epithelial cells. Deregulation of complement system, degradation of antibacterial peptides, and destruction of phagocyte functions facilitate the evasion of P. gingivalis. Porphyromonas gingivalis can also suppress adaptive immunity, which allows P. gingivalis to exist in the host tissues and cause the inflammatory response persistently. Here, we review studies devoted to understanding the strategies utilized by P. gingivalis to escape host immunity. Methods for impairing P. gingivalis immune evasion are also mentioned.
Bibliographie:Funding information
This work was funded by the Cultivation project of Young, Scientific and technological talents in the Department of Education of Liaoning Province (QN2019020 to Chen Li), the National Nature Science Foundation of China, Beijing, China (81870771 to Yaping Pan, 81970942 to Li Lin, 81800974 to Hongyan Wang), and PhD research startup foundation of Liaoning Province (20180540096 to Hongyan Wang).
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ISSN:0022-3484
1600-0765
1600-0765
DOI:10.1111/jre.12915