Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation

[Display omitted] •Pyrrolo[3,4-c]quinoline-1,3-diones were prepared by cyclization cascade reactions.•New class of potent hDHODH inhibitory demonstrated better activity than leflunomide.•Very low cytotoxicity against healthy HaCaT cells was observed.•The optimal lipophilicity was determined at physi...

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