Dynamic structure–function coupling across three major psychiatric disorders

Convergent evidence has suggested atypical relationships between brain structure and function in major psychiatric disorders, yet how the abnormal patterns coincide and/or differ across different disorders remains largely unknown. Here, we aim to investigate the common and/or unique dynamic structur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Psychological medicine Jg. 54; H. 8; S. 1629 - 1640
Hauptverfasser: Zhang, Zhe, Wei, Wei, Wang, Sujie, Li, Mingli, Li, Xiaojing, Li, Xiaoyu, Wang, Qiang, Yu, Hua, Zhang, Yamin, Guo, Wanjun, Ma, Xiaohong, Zhao, Liansheng, Deng, Wei, Sham, Pak C, Sun, Yu, Li, Tao
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Cambridge University Press 01.06.2024
Schlagworte:
Biological markers
Bipolar disorder
Brain
Brain research
Brain structure
Cognition
Cognitive impairment
Cognitive-behavioral factors
Communication
Depressive personality disorders
Disorders
Forensic evidence
Function
Functional anatomy
Functional morphology
Global local relationship
Magnetic resonance imaging
Mental depression
Mental disorders
Networks
Neurodevelopmental disorders
Patients
Schizophrenia
Structure-function relationships
China
cognitive deficits
bipolar disorder
major depressive disorder
neurodevelopment
structure–function coupling
illness-specific
rich-club organization
schizophrenia
brain networks
transdiagnostic
dynamic states
psychiatric disorders
ISSN:0033-2917, 1469-8978, 1469-8978
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Convergent evidence has suggested atypical relationships between brain structure and function in major psychiatric disorders, yet how the abnormal patterns coincide and/or differ across different disorders remains largely unknown. Here, we aim to investigate the common and/or unique dynamic structure-function coupling patterns across major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). We quantified the dynamic structure-function coupling in 452 patients with psychiatric disorders (MDD/BD/SZ = 166/168/118) and 205 unaffected controls at three distinct brain network levels, such as global, meso-, and local levels. We also correlated dynamic structure-function coupling with the topological features of functional networks to examine how the structure-function relationship facilitates brain information communication over time. The dynamic structure-function coupling is preserved for the three disorders at the global network level. Similar abnormalities in the rich-club organization are found in two distinct functional configuration states at the meso-level and are associated with the disease severity of MDD, BD, and SZ. At the local level, shared and unique alterations are observed in the brain regions involving the visual, cognitive control, and default mode networks. In addition, the relationships between structure-function coupling and the topological features of functional networks are altered in a manner indicative of state specificity. These findings suggest both transdiagnostic and illness-specific alterations in the dynamic structure-function relationship of large-scale brain networks across MDD, BD, and SZ, providing new insights and potential biomarkers into the neurodevelopmental basis underlying the behavioral and cognitive deficits observed in these disorders.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0033-2917
1469-8978
1469-8978
DOI:10.1017/S0033291723003525