Association of late-life changes in blood pressure and cognitive status
Disagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to examine whether 4-year changes in systolic and diastolic blood pressure (SBP and DBP) are associated with cognitive status in a representative sample of older men and women. Analysis of lon...
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| Published in: | Journal of geriatric cardiology : JGC Vol. 13; no. 1; pp. 37 - 43 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
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01.01.2016
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| ISSN: | 1671-5411 |
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| Abstract | Disagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to examine whether 4-year changes in systolic and diastolic blood pressure (SBP and DBP) are associated with cognitive status in a representative sample of older men and women.
Analysis of longitudinal data from 854 participants of a population-based German sample (aged 60-87 years) was performed with standard cognitive screening and blood pressure measurements. Effects of changes in SBP and DBP (10 mmHg and 5 mmHg respectively as unit of regression effect measure) on cognitive status were evaluated using non-parametric and linear regression modeling.
No clear associations were seen between changes in SBP or in DBP and cognitive scores. Small effects were found after stratification for sex and hypertension awareness. Specifically, larger decreases in SBP were associated with higher cognitive scores in those men aware of their hypertension (10 mmHg decrease in SBP, β = -0.26, 95% CI: -0.51 to -0.02) and men with controlled hypertension (10 mmHg decrease in SBP, β = -0.44, 95% CI: -0.92 to -0.03). Additionally larger increases in DBP were associated with higher cognitive scores in men with controlled hypertension (5 mmHg increase in DBP, β = 0.67, 95% CI: 0.19-1.15). For women aware of their hypertension, larger decreases in DBP were associated with higher cognitive scores (5 mmHg decrease in DBP, β = -0.26; 95%CI: -0.51 to -0.01).
Changes in blood pressure were only weakly associated with cognitive status. Specifically, decreases in SBP were associated with higher cognitive scores in men aware of their hypertension and especially those that were medically controlled. |
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| AbstractList | BACKGROUNDDisagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to examine whether 4-year changes in systolic and diastolic blood pressure (SBP and DBP) are associated with cognitive status in a representative sample of older men and women.METHODSAnalysis of longitudinal data from 854 participants of a population-based German sample (aged 60-87 years) was performed with standard cognitive screening and blood pressure measurements. Effects of changes in SBP and DBP (10 mmHg and 5 mmHg respectively as unit of regression effect measure) on cognitive status were evaluated using non-parametric and linear regression modeling.RESULTSNo clear associations were seen between changes in SBP or in DBP and cognitive scores. Small effects were found after stratification for sex and hypertension awareness. Specifically, larger decreases in SBP were associated with higher cognitive scores in those men aware of their hypertension (10 mmHg decrease in SBP, β = -0.26, 95% CI: -0.51 to -0.02) and men with controlled hypertension (10 mmHg decrease in SBP, β = -0.44, 95% CI: -0.92 to -0.03). Additionally larger increases in DBP were associated with higher cognitive scores in men with controlled hypertension (5 mmHg increase in DBP, β = 0.67, 95% CI: 0.19-1.15). For women aware of their hypertension, larger decreases in DBP were associated with higher cognitive scores (5 mmHg decrease in DBP, β = -0.26; 95%CI: -0.51 to -0.01).CONCLUSIONSChanges in blood pressure were only weakly associated with cognitive status. Specifically, decreases in SBP were associated with higher cognitive scores in men aware of their hypertension and especially those that were medically controlled. Disagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to examine whether 4-year changes in systolic and diastolic blood pressure (SBP and DBP) are associated with cognitive status in a representative sample of older men and women. Analysis of longitudinal data from 854 participants of a population-based German sample (aged 60-87 years) was performed with standard cognitive screening and blood pressure measurements. Effects of changes in SBP and DBP (10 mmHg and 5 mmHg respectively as unit of regression effect measure) on cognitive status were evaluated using non-parametric and linear regression modeling. No clear associations were seen between changes in SBP or in DBP and cognitive scores. Small effects were found after stratification for sex and hypertension awareness. Specifically, larger decreases in SBP were associated with higher cognitive scores in those men aware of their hypertension (10 mmHg decrease in SBP, β = -0.26, 95% CI: -0.51 to -0.02) and men with controlled hypertension (10 mmHg decrease in SBP, β = -0.44, 95% CI: -0.92 to -0.03). Additionally larger increases in DBP were associated with higher cognitive scores in men with controlled hypertension (5 mmHg increase in DBP, β = 0.67, 95% CI: 0.19-1.15). For women aware of their hypertension, larger decreases in DBP were associated with higher cognitive scores (5 mmHg decrease in DBP, β = -0.26; 95%CI: -0.51 to -0.01). Changes in blood pressure were only weakly associated with cognitive status. Specifically, decreases in SBP were associated with higher cognitive scores in men aware of their hypertension and especially those that were medically controlled. |
| Author | Lacruz, Maria E Haerting, Johannes Kluttig, Alexander Werdan, Karl Tiller, Daniel Greiser, Karin H Nuding, Sebastian |
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| References | 7944835 - Arch Intern Med. 1994 Oct 10;154(19):2154-60 16198188 - J Psychosom Res. 2005 Sep;59(3):153-60 11125239 - Dement Geriatr Cogn Disord. 2001 Jan-Feb;12(1):33-9 10983901 - J Am Geriatr Soc. 2000 Sep;48(9):1035-41 1202204 - J Psychiatr Res. 1975 Nov;12(3):189-98 17332720 - Aging Clin Exp Res. 2007 Feb;19(1):41-7 23126669 - J Am Geriatr Soc. 2012 Nov;60(11):2014-9 14739544 - Dement Geriatr Cogn Disord. 2004;17(3):196-203 16492072 - Drugs Aging. 2006;23(1):83-92 11148234 - Neurology. 2001 Jan 9;56(1):42-8 9495261 - Hypertension. 1998 Mar;31(3):780-6 12711848 - Neuroepidemiology. 2003 May-Jun;22(3):165-71 10448805 - Arch Neurol. 1999 Aug;56(8):991-6 23647314 - J Am Geriatr Soc. 2013 Jun;61(6):875-81 12374512 - Arch Intern Med. 2002 Oct 14;162(18):2046-52 24936139 - Int J Med Sci. 2014 May 29;11(8):771-8 10599763 - Neurology. 1999 Dec 10;53(9):1948-52 18973665 - BMC Med Res Methodol. 2008 Oct 30;8:70 16283930 - BMC Cardiovasc Disord. 2005 Nov 11;5:33 16033691 - Lancet Neurol. 2005 Aug;4(8):487-99 24203797 - J Aging Health. 2013 Dec;25(8):1398-424 2324788 - J Clin Epidemiol. 1990;43(5):475-80 24028355 - J Am Geriatr Soc. 2013 Sep;61(9):1489-98 24434111 - Front Neuroendocrinol. 2014 Aug;35(3):385-403 15184608 - Neurology. 2004 Jun 8;62(11):2021-4 15557506 - Neurology. 2004 Nov 23;63(10):1882-91 11425934 - Neurology. 2001 Jun 26;56(12):1683-9 7500533 - JAMA. 1995 Dec 20;274(23):1846-51 8609748 - Lancet. 1996 Apr 27;347(9009):1141-5 11176727 - Arch Intern Med. 2001 Jan 22;161(2):152-6 8213741 - Am J Epidemiol. 1993 Sep 15;138(6):353-64 12587008 - Int J Obes Relat Metab Disord. 2003 Feb;27(2):260-8 12374517 - Arch Intern Med. 2002 Oct 14;162(18):2090-6 24937034 - Exp Gerontol. 2014 Sep;57:233-42 |
| References_xml | – reference: 12711848 - Neuroepidemiology. 2003 May-Jun;22(3):165-71 – reference: 23126669 - J Am Geriatr Soc. 2012 Nov;60(11):2014-9 – reference: 16033691 - Lancet Neurol. 2005 Aug;4(8):487-99 – reference: 8213741 - Am J Epidemiol. 1993 Sep 15;138(6):353-64 – reference: 24028355 - J Am Geriatr Soc. 2013 Sep;61(9):1489-98 – reference: 11176727 - Arch Intern Med. 2001 Jan 22;161(2):152-6 – reference: 14739544 - Dement Geriatr Cogn Disord. 2004;17(3):196-203 – reference: 18973665 - BMC Med Res Methodol. 2008 Oct 30;8:70 – reference: 11148234 - Neurology. 2001 Jan 9;56(1):42-8 – reference: 2324788 - J Clin Epidemiol. 1990;43(5):475-80 – reference: 23647314 - J Am Geriatr Soc. 2013 Jun;61(6):875-81 – reference: 12374512 - Arch Intern Med. 2002 Oct 14;162(18):2046-52 – reference: 7500533 - JAMA. 1995 Dec 20;274(23):1846-51 – reference: 16198188 - J Psychosom Res. 2005 Sep;59(3):153-60 – reference: 11125239 - Dement Geriatr Cogn Disord. 2001 Jan-Feb;12(1):33-9 – reference: 11425934 - Neurology. 2001 Jun 26;56(12):1683-9 – reference: 8609748 - Lancet. 1996 Apr 27;347(9009):1141-5 – reference: 16492072 - Drugs Aging. 2006;23(1):83-92 – reference: 10983901 - J Am Geriatr Soc. 2000 Sep;48(9):1035-41 – reference: 10599763 - Neurology. 1999 Dec 10;53(9):1948-52 – reference: 24936139 - Int J Med Sci. 2014 May 29;11(8):771-8 – reference: 1202204 - J Psychiatr Res. 1975 Nov;12(3):189-98 – reference: 16283930 - BMC Cardiovasc Disord. 2005 Nov 11;5:33 – reference: 24434111 - Front Neuroendocrinol. 2014 Aug;35(3):385-403 – reference: 12374517 - Arch Intern Med. 2002 Oct 14;162(18):2090-6 – reference: 15557506 - Neurology. 2004 Nov 23;63(10):1882-91 – reference: 9495261 - Hypertension. 1998 Mar;31(3):780-6 – reference: 15184608 - Neurology. 2004 Jun 8;62(11):2021-4 – reference: 24203797 - J Aging Health. 2013 Dec;25(8):1398-424 – reference: 12587008 - Int J Obes Relat Metab Disord. 2003 Feb;27(2):260-8 – reference: 7944835 - Arch Intern Med. 1994 Oct 10;154(19):2154-60 – reference: 17332720 - Aging Clin Exp Res. 2007 Feb;19(1):41-7 – reference: 10448805 - Arch Neurol. 1999 Aug;56(8):991-6 – reference: 24937034 - Exp Gerontol. 2014 Sep;57:233-42 |
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| Snippet | Disagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to examine whether 4-year changes in systolic and... BACKGROUNDDisagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to examine whether 4-year changes in... |
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| Title | Association of late-life changes in blood pressure and cognitive status |
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