Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics

T cells require a co‐stimulatory signal in addition to T‐cell receptor (TCR) stimulation to achieve full activation. While most studies focus on the co‐stimulatory receptor CD28, little is known about the role of the other co‐stimulatory receptors in T‐cell signaling. A deeper understanding of how c...

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Veröffentlicht in:Advanced therapeutics Jg. 5; H. 4
Hauptverfasser: Schluck, Marjolein, Eggermont, Loek J., Weiden, Jorieke, Popelier, Carlijn, Weiss, Lea, Pilzecker, Bas, Kolder, Sigrid, Heinemans, Anne, Rodriguez Mogeda, Carla, Verdoes, Martijn, Figdor, Carl G., Hammink, Roel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: 01.04.2022
Schlagworte:
artificial APC
co‐stimulation
differentiation
human T cells
phenotype
ISSN:2366-3987, 2366-3987
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Abstract T cells require a co‐stimulatory signal in addition to T‐cell receptor (TCR) stimulation to achieve full activation. While most studies focus on the co‐stimulatory receptor CD28, little is known about the role of the other co‐stimulatory receptors in T‐cell signaling. A deeper understanding of how co‐stimulatory receptor signaling cooperates with TCR signaling could improve the ability to control T‐cell function and benefit the design of T‐cell based immunotherapies. Artificial antigen presenting cells (aAPCs) enable tight control over the signals given to T cells. In this study, filamentous polyisocyanopeptide (PIC) polymers (immunofilaments) are used as nanosized aAPCs to study the role of the engagement of six distinct co‐stimulatory molecules on human T‐cell phenotype, function, and fate in the context of TCR signaling. The immunofilaments highlight important roles for CD28 and CD2 signaling in T‐cell priming, proliferation, cytokine production, and multifunctionality. Taken together, this work provides insight into the role of combined TCR and co‐stimulation on T‐cell phenotype, function, and fate using immunofilaments. Notably, the findings on the roles of co‐stimulatory molecule function can be used for the rational design of future cancer immunotherapies. Co‐stimulation is the key to full‐blown T‐cell activation. Filamentous shaped artificial antigen‐presenting cells offer a unique opportunity to directly study the role of combined T‐cell receptor (TCR) and co‐stimulatory receptor stimulation. The phenotype, function, and fate of human T cells after in vitro stimulation are mostly influenced with αCD28 and αCD2 co‐stimulation.
AbstractList T cells require a co‐stimulatory signal in addition to T‐cell receptor (TCR) stimulation to achieve full activation. While most studies focus on the co‐stimulatory receptor CD28, little is known about the role of the other co‐stimulatory receptors in T‐cell signaling. A deeper understanding of how co‐stimulatory receptor signaling cooperates with TCR signaling could improve the ability to control T‐cell function and benefit the design of T‐cell based immunotherapies. Artificial antigen presenting cells (aAPCs) enable tight control over the signals given to T cells. In this study, filamentous polyisocyanopeptide (PIC) polymers (immunofilaments) are used as nanosized aAPCs to study the role of the engagement of six distinct co‐stimulatory molecules on human T‐cell phenotype, function, and fate in the context of TCR signaling. The immunofilaments highlight important roles for CD28 and CD2 signaling in T‐cell priming, proliferation, cytokine production, and multifunctionality. Taken together, this work provides insight into the role of combined TCR and co‐stimulation on T‐cell phenotype, function, and fate using immunofilaments. Notably, the findings on the roles of co‐stimulatory molecule function can be used for the rational design of future cancer immunotherapies. Co‐stimulation is the key to full‐blown T‐cell activation. Filamentous shaped artificial antigen‐presenting cells offer a unique opportunity to directly study the role of combined T‐cell receptor (TCR) and co‐stimulatory receptor stimulation. The phenotype, function, and fate of human T cells after in vitro stimulation are mostly influenced with αCD28 and αCD2 co‐stimulation.
Author Schluck, Marjolein
Figdor, Carl G.
Kolder, Sigrid
Eggermont, Loek J.
Heinemans, Anne
Weiden, Jorieke
Verdoes, Martijn
Rodriguez Mogeda, Carla
Popelier, Carlijn
Pilzecker, Bas
Hammink, Roel
Weiss, Lea
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CitedBy_id crossref_primary_10_1016_j_jconrel_2023_03_028
crossref_primary_10_1002_adhm_202301109
crossref_primary_10_1016_j_ccell_2023_05_014
crossref_primary_10_1021_acsbiomaterials_5c00134
crossref_primary_10_1002_eji_202350658
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References_xml – volume: 229
  start-page: 216
  year: 2009
  publication-title: Immunol. Rev.
– volume: 192
  start-page: 161
  year: 2003
  publication-title: Immunol. Rev.
– volume: 15
  start-page: 486
  year: 2015
  publication-title: Nat. Rev. Immunol.
– volume: 32
  start-page: 3617
  year: 2002
  publication-title: Eur. J. Immunol.
– volume: 460
  start-page: 399
  year: 2014
  publication-title: Biochem. J.
– volume: 362
  start-page: 131
  year: 2010
  publication-title: J. Immunol. Methods
– volume: 31
  start-page: 787
  year: 2009
  publication-title: Immunity
– volume: 12
  start-page: 269
  year: 2012
  publication-title: Nat. Rev. Immunol.
– volume: 57
  start-page: 175
  year: 2007
  publication-title: Cancer Immunol. Immunother.
– volume: 105
  start-page: 7791
  year: 2008
  publication-title: Proc. Natl. Acad. Sci.
– volume: 12
  start-page: 448
  year: 2000
  publication-title: Curr. Opin. Immunol.
– volume: 46
  start-page: S52
  year: 2000
  publication-title: Cancer Chemother. Pharmacol.
– volume: 32
  start-page: 456
  year: 2014
  publication-title: Trends Biotechnol.
– volume: 54
  start-page: 74
  year: 2017
  publication-title: Cancer Treat. Rev.
– volume: 71
  start-page: 4617
  year: 2011
  publication-title: Cancer Res.
– volume: 21
  start-page: 693
  year: 2004
  publication-title: Immunity
– volume: 129
  start-page: 2935
  year: 2011
  publication-title: Int. J. Cancer
– volume: 10
  start-page: 485
  year: 2015
  publication-title: ACS Chem. Biol.
– volume: 1344
  year: 2016
  publication-title: Methods Mol. Biol.
– volume: 113
  start-page: 5167
  year: 2009
  publication-title: Blood.
– volume: 22
  start-page: 333
  year: 2010
  publication-title: Curr. Opin. Immunol.
– volume: 12
  start-page: 298
  year: 2012
  publication-title: Nat. Rev. Cancer.
– volume: 8
  start-page: 247
  year: 2008
  publication-title: Nat. Rev. Immunol.
– volume: 19
  start-page: 281
  year: 2007
  publication-title: Curr. Opin. Immunol.
– volume: 141
  start-page: 494
  year: 2012
  publication-title: Chest
– volume: 1
  year: 2018
  publication-title: Adv. Ther.
– volume: 13
  start-page: 227
  year: 2013
  publication-title: Nat. Rev. Immunol.
– volume: 4
  start-page: 53
  year: 2013
  publication-title: Front. Immunol.
– volume: 189
  start-page: 4331
  year: 2012
  publication-title: J. Immunol.
– volume: 7
  start-page: 655
  year: 2015
  publication-title: Immunotherapy
– volume: 85
  start-page: 9
  year: 2000
  publication-title: Ann. Allergy, Asthma, Immunol.
– volume: 21
  start-page: 581
  year: 2015
  publication-title: Nat. Med.
– volume: 2
  start-page: 937
  year: 2017
  publication-title: ACS Omega
– volume: 29
  start-page: 665
  year: 2011
  publication-title: Annu. Rev. Immunol.
– volume: 193
  start-page: 244
  year: 2014
  publication-title: J. Immunol.
– volume: 150
  start-page: 1
  year: 2013
  publication-title: Immunol. Lett.
– volume: 43
  start-page: 2797
  year: 2013
  publication-title: Eur. J. Immunol.
– volume: 172
  start-page: 6039
  year: 2004
  publication-title: J. Immunol.
– volume: 91
  start-page: 53
  year: 2012
  publication-title: Eur. J. Cell Biol.
– volume: 5
  year: 2016
  publication-title: Oncoimmunology
– volume: 30
  year: 2018
  publication-title: Adv. Mater.
– volume: 21
  start-page: 1232
  year: 2020
  publication-title: Nat. Immunol.
– volume: 28
  start-page: 2560
  year: 2017
  publication-title: Bioconjugate Chem.
– volume: 90
  start-page: 6586
  year: 1993
  publication-title: Proc. Natl. Acad. Sci.
– volume: 4
  start-page: 4168
  year: 2013
  publication-title: Chem. Sci.
– volume: 3
  start-page: 37
  year: 2015
  publication-title: J. Immunother. Cancer
– volume: 185
  start-page: 521
  year: 2009
  publication-title: J. Cell Biol.
– volume: 38
  start-page: 350
  year: 2008
  publication-title: Eur. J. Immunol.
– volume: 9
  start-page: 7826
  year: 2019
  publication-title: Theranostics
– volume: 4
  start-page: 772
  year: 2021
  publication-title: Commun. Biol.
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Snippet T cells require a co‐stimulatory signal in addition to T‐cell receptor (TCR) stimulation to achieve full activation. While most studies focus on the...
SourceID wiley
SourceType Publisher
SubjectTerms artificial APC
co‐stimulation
differentiation
human T cells
phenotype
Title Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadtp.202200019
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