Sex differences in behavior, immune function, and redox state throughout life, and their effect on the longevity of Swiss mice

Homeostatic systems (nervous, immune, and endocrine) are crucial for maintaining health throughout life and, consequently, relevant for the rate of aging and the longevity achieved. In many species, male and female mammals show different lifespans, attributed to distinct redox states, but it is scar...

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Vydáno v:	Biogerontology (Dordrecht) Ročník 26; číslo 6; s. 204
Hlavní autoři:	Félix, Judith, Garrido, Antonio, De la Fuente, Mónica
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer Netherlands 14.11.2025 Springer Nature B.V
Témata:	Age Age Factors Aging Aging - immunology Animals Anxiety Behavior Behavior, Animal - physiology Biological markers Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Cell Biology Deaths Design of experiments Developmental Biology Estrogens Female Females Function Gender differences Geriatrics/Gerontology Hormones Immune response Immune system Immune System - physiology Immunity, Innate Laboratory animals Leukocytes Life expectancy Life Sciences Longevity Longevity - immunology Longevity - physiology Longitudinal studies Male Males Mental health Mice Motor ability Nutrition research Oxidation-Reduction Oxidative Stress Preservation Redox properties Research Article Research design Sex Characteristics Sex differences Sex Factors Sexes Spain Aging Redox state Sex differences Immunology Behavior Longevity
ISSN:	1389-5729, 1573-6768, 1573-6768
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Abstract	Homeostatic systems (nervous, immune, and endocrine) are crucial for maintaining health throughout life and, consequently, relevant for the rate of aging and the longevity achieved. In many species, male and female mammals show different lifespans, attributed to distinct redox states, but it is scarcely known whether sex differences in the functioning of these systems are involved. This study investigated, in an integrative view, sex differences in the nervous and immune systems of Swiss strain mice by analyzing behavior, immune function, and redox biomarkers across aging, to determine whether possible sex differences in homeostatic systems affect longevity. A longitudinal study was conducted on 20 female and male Swiss mice. At their young (2 mon), adult (7 mon), and old (18 mon) ages, subjects were subjected to a battery of behavioral tests, and peritoneal leukocytes were extracted to assess immune function and redox biomarkers. The natural deaths of animals were recorded for a longevity study. Our results indicate that sexual differences begin at a young age, and several are maintained until old age. Females, in general, show better behavior, immune function, and redox biomarkers, contributing to their higher longevity compared to males. The enhanced longevity in females may be attributable, in part, to the preservation of robust immune competence, with emphasis on innate immune functions and lower oxidative stress. The integration of behavioral and immunological profiles, together with redox biomarkers, underscores the critical importance of incorporating both sex as a biological variable in the design of aging-related research.
AbstractList	Homeostatic systems (nervous, immune, and endocrine) are crucial for maintaining health throughout life and, consequently, relevant for the rate of aging and the longevity achieved. In many species, male and female mammals show different lifespans, attributed to distinct redox states, but it is scarcely known whether sex differences in the functioning of these systems are involved. This study investigated, in an integrative view, sex differences in the nervous and immune systems of Swiss strain mice by analyzing behavior, immune function, and redox biomarkers across aging, to determine whether possible sex differences in homeostatic systems affect longevity. A longitudinal study was conducted on 20 female and male Swiss mice. At their young (2 mon), adult (7 mon), and old (18 mon) ages, subjects were subjected to a battery of behavioral tests, and peritoneal leukocytes were extracted to assess immune function and redox biomarkers. The natural deaths of animals were recorded for a longevity study. Our results indicate that sexual differences begin at a young age, and several are maintained until old age. Females, in general, show better behavior, immune function, and redox biomarkers, contributing to their higher longevity compared to males. The enhanced longevity in females may be attributable, in part, to the preservation of robust immune competence, with emphasis on innate immune functions and lower oxidative stress. The integration of behavioral and immunological profiles, together with redox biomarkers, underscores the critical importance of incorporating both sex as a biological variable in the design of aging-related research. Homeostatic systems (nervous, immune, and endocrine) are crucial for maintaining health throughout life and, consequently, relevant for the rate of aging and the longevity achieved. In many species, male and female mammals show different lifespans, attributed to distinct redox states, but it is scarcely known whether sex differences in the functioning of these systems are involved. This study investigated, in an integrative view, sex differences in the nervous and immune systems of Swiss strain mice by analyzing behavior, immune function, and redox biomarkers across aging, to determine whether possible sex differences in homeostatic systems affect longevity. A longitudinal study was conducted on 20 female and male Swiss mice. At their young (2 mon), adult (7 mon), and old (18 mon) ages, subjects were subjected to a battery of behavioral tests, and peritoneal leukocytes were extracted to assess immune function and redox biomarkers. The natural deaths of animals were recorded for a longevity study. Our results indicate that sexual differences begin at a young age, and several are maintained until old age. Females, in general, show better behavior, immune function, and redox biomarkers, contributing to their higher longevity compared to males. The enhanced longevity in females may be attributable, in part, to the preservation of robust immune competence, with emphasis on innate immune functions and lower oxidative stress. The integration of behavioral and immunological profiles, together with redox biomarkers, underscores the critical importance of incorporating both sex as a biological variable in the design of aging-related research. Homeostatic systems (nervous, immune, and endocrine) are crucial for maintaining health throughout life and, consequently, relevant for the rate of aging and the longevity achieved. In many species, male and female mammals show different lifespans, attributed to distinct redox states, but it is scarcely known whether sex differences in the functioning of these systems are involved. This study investigated, in an integrative view, sex differences in the nervous and immune systems of Swiss strain mice by analyzing behavior, immune function, and redox biomarkers across aging, to determine whether possible sex differences in homeostatic systems affect longevity. A longitudinal study was conducted on 20 female and male Swiss mice. At their young (2 mon), adult (7 mon), and old (18 mon) ages, subjects were subjected to a battery of behavioral tests, and peritoneal leukocytes were extracted to assess immune function and redox biomarkers. The natural deaths of animals were recorded for a longevity study. Our results indicate that sexual differences begin at a young age, and several are maintained until old age. Females, in general, show better behavior, immune function, and redox biomarkers, contributing to their higher longevity compared to males. The enhanced longevity in females may be attributable, in part, to the preservation of robust immune competence, with emphasis on innate immune functions and lower oxidative stress. The integration of behavioral and immunological profiles, together with redox biomarkers, underscores the critical importance of incorporating both sex as a biological variable in the design of aging-related research.Homeostatic systems (nervous, immune, and endocrine) are crucial for maintaining health throughout life and, consequently, relevant for the rate of aging and the longevity achieved. In many species, male and female mammals show different lifespans, attributed to distinct redox states, but it is scarcely known whether sex differences in the functioning of these systems are involved. This study investigated, in an integrative view, sex differences in the nervous and immune systems of Swiss strain mice by analyzing behavior, immune function, and redox biomarkers across aging, to determine whether possible sex differences in homeostatic systems affect longevity. A longitudinal study was conducted on 20 female and male Swiss mice. At their young (2 mon), adult (7 mon), and old (18 mon) ages, subjects were subjected to a battery of behavioral tests, and peritoneal leukocytes were extracted to assess immune function and redox biomarkers. The natural deaths of animals were recorded for a longevity study. Our results indicate that sexual differences begin at a young age, and several are maintained until old age. Females, in general, show better behavior, immune function, and redox biomarkers, contributing to their higher longevity compared to males. The enhanced longevity in females may be attributable, in part, to the preservation of robust immune competence, with emphasis on innate immune functions and lower oxidative stress. The integration of behavioral and immunological profiles, together with redox biomarkers, underscores the critical importance of incorporating both sex as a biological variable in the design of aging-related research.
ArticleNumber	204
Author	Garrido, Antonio Félix, Judith De la Fuente, Mónica
Author_xml	– sequence: 1 givenname: Judith orcidid: 0000-0003-3319-7623 surname: Félix fullname: Félix, Judith organization: Department of Genetics, Physiology and Microbiology. School of Biology, Complutense University of Madrid, Institute of Investigation Hospital 12 de Octubre (i+12), Hospital 12 de Octubre – sequence: 2 givenname: Antonio orcidid: 0000-0003-3026-3330 surname: Garrido fullname: Garrido, Antonio email: antonio.garrido@universidadeuropea.es organization: Institute of Investigation Hospital 12 de Octubre (i+12), Hospital 12 de Octubre, Nanocaging Research Group, Department of Biosciences, School of Biomedical Sciences and Health, Universidad Europea de Madrid – sequence: 3 givenname: Mónica orcidid: 0000-0002-5969-097X surname: De la Fuente fullname: De la Fuente, Mónica organization: Department of Genetics, Physiology and Microbiology. School of Biology, Complutense University of Madrid, Institute of Investigation Hospital 12 de Octubre (i+12), Hospital 12 de Octubre
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Cites_doi	10.1016/j.it.2015.09.009 10.1016/j.redox.2020.101488 10.1007/s00424-013-1271-7 10.1016/j.yfrne.2014.03.005 10.1038/s41598-022-06395-1 10.1016/j.nut.2006.05.007 10.1080/17461391.2021.1921854 10.1111/acel.13891 10.1002/bdrb.20106 10.1016/j.sjbs.2021.04.010 10.1126/science.493989 10.1038/s41392-023-01451-2 10.1016/s0041-008x(03)00099-1 10.1002/hbm.24481 10.1007/s10522-020-09902-x 10.1093/gerona/glac042 10.1016/j.mad.2023.111802 10.3390/ijms20030769 10.1016/j.neubiorev.2021.11.014 10.1016/j.mayocp.2020.07.033 10.1093/gerona/glz033 10.2174/138161211798764942 10.1016/0531-5565(78)90049-9 10.1155/2019/4574276 10.1016/j.redox.2013.05.003 10.1016/j.physbeh.2009.09.017 10.1007/s10522-004-3201-8 10.1016/j.neuroscience.2012.09.077 10.1210/en.2018.00220 10.18632/aging.101116 10.1007/978-3-319-99375-1_115 10.1016/j.ejphar.2009.11.001 10.1016/j.mad2023.111798 10.1016/s0031-9384(01)00494-2 10.1126/science.abo3191 10.4077/CJP.2011.AMM080 10.1016/j.cellimm.2011.10.009 10.1016/j.redox.2017.03.005 10.1016/j.cmet.2016.05.019 10.1371/journal.pone.0046111 10.3389/fimmu.2022.1031924 10.1016/j.bbi.2018.01.003 10.3390/cells10112974 10.1152/physrev.00039.2016 10.1038/s41577-025-01199-6 10.1523/JNEUROSCI.1233-24.2024 10.1093/gerona/glae181 10.1016/j.neuroscience.2024.06.020 10.1038/s41577-024-00996-9 10.1515/BC.2008.027 10.1016/j.neuron.2016.12.001 10.1016/j.comppsych.2018.10.008 10.1007/s10522-010-9317-0 10.1016/j.bbi.2017.02.006 10.1016/j.brainres.2009.05.029 10.1073/pnas.1012406108 10.1111/acel.13542 10.1002/bmc.3529 10.1016/0091-3057(94)00314-9 10.1016/j.yhbeh.2007.05.006 10.2174/138161209789058110 10.1046/j.1365-2265.2002.01657.x
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References	I Martínez de Toda (10350_CR41) 2016; 8 M Bekhbat (10350_CR7) 2018; 67 J Miquel (10350_CR47) 1978; 13 AA Alodhayani (10350_CR3) 2021; 28 I Martínez de Toda (10350_CR43) 2020; 75 R Kanďár (10350_CR32) 2016; 30 C Massafra (10350_CR45) 2002; 57 SA Laredo (10350_CR38) 2015; 35 N Jiang (10350_CR31) 2023; 22 DKJ Pieren (10350_CR50) 2022; 13 10350_CR25 DL Dickstein (10350_CR19) 2012; 251 I Klöting (10350_CR33) 2003; 189 A Garrido (10350_CR27) 2019; 20 C Mayer (10350_CR46) 2020; 107 M Reiber (10350_CR52) 2022; 12 C Carmody (10350_CR15) 2022; 77 I Martínez de Toda (10350_CR44) 2021; 10 M la De Fuente (10350_CR37) 2009; 15 M De la Fuente (10350_CR18) 2004; 5 I Martínez de Toda (10350_CR42) 2019; 2019 J Félix (10350_CR23) 2024; 79 Z Liu (10350_CR40) 2023; 8 H Kobayashi (10350_CR34) 2021; 22 F Bellanti (10350_CR9) 2013; 1 C Bories (10350_CR10) 2012; 7 K Kowalska (10350_CR35) 2016; 46 SJ Buell (10350_CR13) 1979 MW Pataky (10350_CR49) 2021; 96 ES Gollwitzer (10350_CR30) 2015; 36 VV Dukhande (10350_CR21) 2009; 1286 I Baeza (10350_CR6) 2011; 12 LM Suárez (10350_CR56) 2023; 211 R Dantzer (10350_CR17) 2017; 98 M Abdullah (10350_CR1) 2012; 272 AG Roberts (10350_CR53) 2019 DW Brann (10350_CR11) 2022; 132 J Tower (10350_CR58) 2020; 31 P Palanza (10350_CR48) 2001; 73 SE Alexander (10350_CR2) 2022; 22 Y Chen (10350_CR16) 2011; 54 JM Goldman (10350_CR29) 2007; 80 AM Bronikowski (10350_CR12) 2022; 21 A Garrido (10350_CR26) 2018; 69 KS Forsyth (10350_CR24) 2024; 24 A Leunig (10350_CR39) 2025 L Gioiosa (10350_CR28) 2007; 52 C Alvarado (10350_CR63) 2006; 22 J Tiberi (10350_CR57) 2023; 211 NC Donner (10350_CR20) 2013; 465 F Kurth (10350_CR36) 2019; 40 MR Bell (10350_CR8) 2018; 159 J Viña (10350_CR61) 2011; 17 MN Economo (10350_CR22) 2024; 44 J Viña (10350_CR60) 2008; 389 C Vida (10350_CR59) 2017; 12 H Rammal (10350_CR51) 2010; 627 V Sreenivasan (10350_CR55) 2016; 92 SN Austand (10350_CR5) 2016; 23 AA Walf (10350_CR62) 2010; 99 De Cabo (10350_CR14) 1995; 50 MB Sleiman (10350_CR54) 2022; 377 J Alves (10350_CR4) 2024; 553
References_xml	– volume: 36 start-page: 684 issue: 11 year: 2015 ident: 10350_CR30 publication-title: Trends Immunol doi: 10.1016/j.it.2015.09.009 – volume: 31 year: 2020 ident: 10350_CR58 publication-title: Redox Biol doi: 10.1016/j.redox.2020.101488 – volume: 465 start-page: 601 issue: 5 year: 2013 ident: 10350_CR20 publication-title: Pflugers Arch doi: 10.1007/s00424-013-1271-7 – volume: 35 start-page: 447 issue: 4 year: 2015 ident: 10350_CR38 publication-title: Front Neuroendocrinol doi: 10.1016/j.yfrne.2014.03.005 – volume: 12 start-page: 2550 issue: 1 year: 2022 ident: 10350_CR52 publication-title: Sci Rep doi: 10.1038/s41598-022-06395-1 – volume: 22 start-page: 767 issue: 7-8 year: 2006 ident: 10350_CR63 publication-title: Nutrition doi: 10.1016/j.nut.2006.05.007 – volume: 22 start-page: 1035 issue: 7 year: 2022 ident: 10350_CR2 publication-title: Eur J Sport Sci doi: 10.1080/17461391.2021.1921854 – volume: 22 issue: 8 year: 2023 ident: 10350_CR31 publication-title: Aging Cell doi: 10.1111/acel.13891 – volume: 80 start-page: 84 issue: 2 year: 2007 ident: 10350_CR29 publication-title: Birth Defects Res B Dev Reprod Toxicol doi: 10.1002/bdrb.20106 – volume: 28 start-page: 4005 issue: 7 year: 2021 ident: 10350_CR3 publication-title: Saudi J Biol Sci doi: 10.1016/j.sjbs.2021.04.010 – year: 1979 ident: 10350_CR13 publication-title: Science doi: 10.1126/science.493989 – volume: 8 start-page: 200 year: 2023 ident: 10350_CR40 publication-title: Sign Transd Targ Ther doi: 10.1038/s41392-023-01451-2 – volume: 189 start-page: 68 issue: 1 year: 2003 ident: 10350_CR33 publication-title: Toxicol Appl Pharmacol doi: 10.1016/s0041-008x(03)00099-1 – volume: 40 start-page: 1697 issue: 6 year: 2019 ident: 10350_CR36 publication-title: Hum Brain Mapp doi: 10.1002/hbm.24481 – volume: 22 start-page: 49 issue: 1 year: 2021 ident: 10350_CR34 publication-title: Biogerontology doi: 10.1007/s10522-020-09902-x – volume: 77 start-page: 2177 issue: 11 year: 2022 ident: 10350_CR15 publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glac042 – volume: 211 year: 2023 ident: 10350_CR57 publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2023.111802 – volume: 20 start-page: 769 year: 2019 ident: 10350_CR27 publication-title: Int J Mol Sci doi: 10.3390/ijms20030769 – volume: 132 start-page: 793 year: 2022 ident: 10350_CR11 publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2021.11.014 – volume: 96 start-page: 788 issue: 3 year: 2021 ident: 10350_CR49 publication-title: Mayo Clin Proc doi: 10.1016/j.mayocp.2020.07.033 – volume: 75 start-page: 613 issue: 4 year: 2020 ident: 10350_CR43 publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glz033 – volume: 17 start-page: 3959 issue: 36 year: 2011 ident: 10350_CR61 publication-title: Curr Pharm des doi: 10.2174/138161211798764942 – volume: 13 start-page: 389 issue: 6 year: 1978 ident: 10350_CR47 publication-title: Exp Gerontol doi: 10.1016/0531-5565(78)90049-9 – volume: 2019 start-page: 4574276 issue: 1 year: 2019 ident: 10350_CR42 publication-title: Oxidative Med Cellular Longevity doi: 10.1155/2019/4574276 – volume: 1 start-page: 340 issue: 1 year: 2013 ident: 10350_CR9 publication-title: Redox Biol doi: 10.1016/j.redox.2013.05.003 – volume: 99 start-page: 169 issue: 2 year: 2010 ident: 10350_CR62 publication-title: Physiol Behav doi: 10.1016/j.physbeh.2009.09.017 – volume: 5 start-page: 389 issue: 6 year: 2004 ident: 10350_CR18 publication-title: Biogerontology doi: 10.1007/s10522-004-3201-8 – volume: 251 start-page: 21 year: 2012 ident: 10350_CR19 publication-title: Neurosci doi: 10.1016/j.neuroscience.2012.09.077 – volume: 159 start-page: 2596 issue: 7 year: 2018 ident: 10350_CR8 publication-title: Endocrinology doi: 10.1210/en.2018.00220 – volume: 8 start-page: 3110 issue: 11 year: 2016 ident: 10350_CR41 publication-title: Aging (Albany NY) doi: 10.18632/aging.101116 – ident: 10350_CR25 doi: 10.1007/978-3-319-99375-1_115 – volume: 627 start-page: 173 year: 2010 ident: 10350_CR51 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2009.11.001 – volume: 211 year: 2023 ident: 10350_CR56 publication-title: Involvement on Longevity Mech Ageing Dev doi: 10.1016/j.mad2023.111798 – volume: 73 start-page: 411 issue: 3 year: 2001 ident: 10350_CR48 publication-title: Physiol Behav doi: 10.1016/s0031-9384(01)00494-2 – volume: 377 start-page: eabo3191 issue: 6614 year: 2022 ident: 10350_CR54 publication-title: Science doi: 10.1126/science.abo3191 – volume: 54 start-page: 385 issue: 6 year: 2011 ident: 10350_CR16 publication-title: Chin J Physiol doi: 10.4077/CJP.2011.AMM080 – volume: 272 start-page: 214 issue: 2 year: 2012 ident: 10350_CR1 publication-title: Cell Immunol doi: 10.1016/j.cellimm.2011.10.009 – volume: 46 start-page: 480 issue: 5 year: 2016 ident: 10350_CR35 publication-title: Ann Clin Lab Sci – volume: 12 start-page: 423 year: 2017 ident: 10350_CR59 publication-title: Redox Biol doi: 10.1016/j.redox.2017.03.005 – volume: 23 start-page: P1022 issue: 6 year: 2016 ident: 10350_CR5 publication-title: Cell MeTable doi: 10.1016/j.cmet.2016.05.019 – volume: 7 issue: 9 year: 2012 ident: 10350_CR10 publication-title: PLoS ONE doi: 10.1371/journal.pone.0046111 – volume: 13 start-page: 1 year: 2022 ident: 10350_CR50 publication-title: Front Immunol doi: 10.3389/fimmu.2022.1031924 – volume: 69 start-page: 440 year: 2018 ident: 10350_CR26 publication-title: Longitudinal Study Brain Behav Immun doi: 10.1016/j.bbi.2018.01.003 – volume: 10 start-page: 2974 issue: 11 year: 2021 ident: 10350_CR44 publication-title: Cells doi: 10.3390/cells10112974 – volume: 98 start-page: 477 issue: 1 year: 2017 ident: 10350_CR17 publication-title: Physiol Rev doi: 10.1152/physrev.00039.2016 – year: 2025 ident: 10350_CR39 publication-title: Nat Rev Immunol doi: 10.1038/s41577-025-01199-6 – volume: 44 issue: 40 year: 2024 ident: 10350_CR22 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1233-24.2024 – volume: 79 issue: 9 year: 2024 ident: 10350_CR23 publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glae181 – volume: 553 start-page: 160 issue: 16 year: 2024 ident: 10350_CR4 publication-title: Neurosci doi: 10.1016/j.neuroscience.2024.06.020 – volume: 24 start-page: 487 issue: 7 year: 2024 ident: 10350_CR24 publication-title: Nat Rev Immunol doi: 10.1038/s41577-024-00996-9 – volume: 389 start-page: 273 issue: 3 year: 2008 ident: 10350_CR60 publication-title: Bchm doi: 10.1515/BC.2008.027 – volume: 92 start-page: 1368 year: 2016 ident: 10350_CR55 publication-title: Neuron doi: 10.1016/j.neuron.2016.12.001 – year: 2019 ident: 10350_CR53 publication-title: Compr Psychiatry doi: 10.1016/j.comppsych.2018.10.008 – volume: 12 start-page: 227 issue: 3 year: 2011 ident: 10350_CR6 publication-title: Biogerontology doi: 10.1007/s10522-010-9317-0 – volume: 67 start-page: 1 year: 2018 ident: 10350_CR7 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2017.02.006 – volume: 1286 start-page: 19 year: 2009 ident: 10350_CR21 publication-title: Brain Res doi: 10.1016/j.brainres.2009.05.029 – volume: 107 start-page: 22693 issue: 52 year: 2020 ident: 10350_CR46 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1012406108 – volume: 21 issue: 2 year: 2022 ident: 10350_CR12 publication-title: Aging Cell doi: 10.1111/acel.13542 – volume: 30 start-page: 13 issue: 1 year: 2016 ident: 10350_CR32 publication-title: Biomed Chromatogr doi: 10.1002/bmc.3529 – volume: 50 start-page: 277 issue: 2 year: 1995 ident: 10350_CR14 publication-title: Pharmacol Biochem Behav doi: 10.1016/0091-3057(94)00314-9 – volume: 52 start-page: 307 issue: 3 year: 2007 ident: 10350_CR28 publication-title: Horm Behav doi: 10.1016/j.yhbeh.2007.05.006 – volume: 15 start-page: 3003 issue: 26 year: 2009 ident: 10350_CR37 publication-title: Curr Pharm des doi: 10.2174/138161209789058110 – volume: 57 start-page: 663 issue: 5 year: 2002 ident: 10350_CR45 publication-title: Clin Endocrinol (Oxf) doi: 10.1046/j.1365-2265.2002.01657.x
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SubjectTerms	Age Age Factors Aging Aging - immunology Animals Anxiety Behavior Behavior, Animal - physiology Biological markers Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Cell Biology Deaths Design of experiments Developmental Biology Estrogens Female Females Function Gender differences Geriatrics/Gerontology Hormones Immune response Immune system Immune System - physiology Immunity, Innate Laboratory animals Leukocytes Life expectancy Life Sciences Longevity Longevity - immunology Longevity - physiology Longitudinal studies Male Males Mental health Mice Motor ability Nutrition research Oxidation-Reduction Oxidative Stress Preservation Redox properties Research Article Research design Sex Characteristics Sex differences Sex Factors Sexes
Title	Sex differences in behavior, immune function, and redox state throughout life, and their effect on the longevity of Swiss mice
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