Glycemic responses of three mango varieties in subjects with and without T2D: a pilot crossover study using OTT and CGM

Mango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D). We conducted a two...

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Published in:European journal of clinical nutrition Vol. 79; no. 10; p. 991
Main Authors: Kehar, Sugandha, Bhatt, Surya Prakash, Pandey, Ravindra M, Ahmad Ansari, Irshad, Palavalli, Rajashekar Reddy, Gupta, Vimal, Misra, Anoop
Format: Journal Article
Language:English
Published: England 01.10.2025
Subjects:
Adult
Aged
Blood Glucose - analysis
Blood Glucose - metabolism
Blood Glucose Self-Monitoring
Bread
Cross-Over Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diet therapy
Diet
Female
Fruit
Glucose Tolerance Test
Glycemic Index
Humans
Male
Mangifera
Middle Aged
Pilot Projects
Postprandial Period
ISSN:1476-5640, 1476-5640
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Summary:Mango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D). We conducted a two-phase study involving 95 participants (45 with T2D, 50 non-diabetic). Phase 1 employed oral tolerance test (OTT) to assess immediate glycemic responses to mango (Safeda, Dasheri, and Langra), bread, and glucose. Phase 2 utilized continuous glucose monitoring (CGM) to evaluate glycemic profiles over three days. On OTT, in non-diabetic subjects, mango consumption resulted in non-significantly lower postprandial glucose peaks compared to glucose and bread, except Langra variety which showed lowest area under the curve for glucose of borderline significance. In subjects with T2D, mango varieties performed similarly to bread. CGM data revealed that mango consumption over three days resulted in a similar glycemic profile to bread in non-diabetic subjects and a lower glycemic profile in subjects with T2D, though most differences were statistically not significant. Mean Amplitude of Glycemic Excursion (MAGE) was significantly lower after mango ingestion as compared to bread in CGM data in subjects with T2D. Data show limited glycemic impact of tested mango varieties, comparable to or lower than white bread, especially in T2D subjects. The significant reduction in MAGE observed with mango consumption suggests potential benefits for glycemic variability. With portion control in calorie restrictive diets, mango may be suitable for people with T2D.
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ISSN:1476-5640
1476-5640
DOI:10.1038/s41430-025-01659-1