Glycemic responses of three mango varieties in subjects with and without T2D: a pilot crossover study using OTT and CGM
Mango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D). We conducted a two...
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| Published in: | European journal of clinical nutrition Vol. 79; no. 10; p. 991 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01.10.2025
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| ISSN: | 1476-5640, 1476-5640 |
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| Abstract | Mango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D).
We conducted a two-phase study involving 95 participants (45 with T2D, 50 non-diabetic). Phase 1 employed oral tolerance test (OTT) to assess immediate glycemic responses to mango (Safeda, Dasheri, and Langra), bread, and glucose. Phase 2 utilized continuous glucose monitoring (CGM) to evaluate glycemic profiles over three days.
On OTT, in non-diabetic subjects, mango consumption resulted in non-significantly lower postprandial glucose peaks compared to glucose and bread, except Langra variety which showed lowest area under the curve for glucose of borderline significance. In subjects with T2D, mango varieties performed similarly to bread. CGM data revealed that mango consumption over three days resulted in a similar glycemic profile to bread in non-diabetic subjects and a lower glycemic profile in subjects with T2D, though most differences were statistically not significant. Mean Amplitude of Glycemic Excursion (MAGE) was significantly lower after mango ingestion as compared to bread in CGM data in subjects with T2D.
Data show limited glycemic impact of tested mango varieties, comparable to or lower than white bread, especially in T2D subjects. The significant reduction in MAGE observed with mango consumption suggests potential benefits for glycemic variability. With portion control in calorie restrictive diets, mango may be suitable for people with T2D. |
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| AbstractList | Mango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D).OBJECTIVESMango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D).We conducted a two-phase study involving 95 participants (45 with T2D, 50 non-diabetic). Phase 1 employed oral tolerance test (OTT) to assess immediate glycemic responses to mango (Safeda, Dasheri, and Langra), bread, and glucose. Phase 2 utilized continuous glucose monitoring (CGM) to evaluate glycemic profiles over three days.METHODSWe conducted a two-phase study involving 95 participants (45 with T2D, 50 non-diabetic). Phase 1 employed oral tolerance test (OTT) to assess immediate glycemic responses to mango (Safeda, Dasheri, and Langra), bread, and glucose. Phase 2 utilized continuous glucose monitoring (CGM) to evaluate glycemic profiles over three days.On OTT, in non-diabetic subjects, mango consumption resulted in non-significantly lower postprandial glucose peaks compared to glucose and bread, except Langra variety which showed lowest area under the curve for glucose of borderline significance. In subjects with T2D, mango varieties performed similarly to bread. CGM data revealed that mango consumption over three days resulted in a similar glycemic profile to bread in non-diabetic subjects and a lower glycemic profile in subjects with T2D, though most differences were statistically not significant. Mean Amplitude of Glycemic Excursion (MAGE) was significantly lower after mango ingestion as compared to bread in CGM data in subjects with T2D.RESULTSOn OTT, in non-diabetic subjects, mango consumption resulted in non-significantly lower postprandial glucose peaks compared to glucose and bread, except Langra variety which showed lowest area under the curve for glucose of borderline significance. In subjects with T2D, mango varieties performed similarly to bread. CGM data revealed that mango consumption over three days resulted in a similar glycemic profile to bread in non-diabetic subjects and a lower glycemic profile in subjects with T2D, though most differences were statistically not significant. Mean Amplitude of Glycemic Excursion (MAGE) was significantly lower after mango ingestion as compared to bread in CGM data in subjects with T2D.Data show limited glycemic impact of tested mango varieties, comparable to or lower than white bread, especially in T2D subjects. The significant reduction in MAGE observed with mango consumption suggests potential benefits for glycemic variability. With portion control in calorie restrictive diets, mango may be suitable for people with T2D.CONCLUSIONSData show limited glycemic impact of tested mango varieties, comparable to or lower than white bread, especially in T2D subjects. The significant reduction in MAGE observed with mango consumption suggests potential benefits for glycemic variability. With portion control in calorie restrictive diets, mango may be suitable for people with T2D. Mango consumption is often restricted in diet consumed by people with diabetes due to concerns about its glycemic impact. This study aimed to compare the glycemic effects of mango consumption with those of white bread and glucose in subjects with and without type 2 diabetes (T2D). We conducted a two-phase study involving 95 participants (45 with T2D, 50 non-diabetic). Phase 1 employed oral tolerance test (OTT) to assess immediate glycemic responses to mango (Safeda, Dasheri, and Langra), bread, and glucose. Phase 2 utilized continuous glucose monitoring (CGM) to evaluate glycemic profiles over three days. On OTT, in non-diabetic subjects, mango consumption resulted in non-significantly lower postprandial glucose peaks compared to glucose and bread, except Langra variety which showed lowest area under the curve for glucose of borderline significance. In subjects with T2D, mango varieties performed similarly to bread. CGM data revealed that mango consumption over three days resulted in a similar glycemic profile to bread in non-diabetic subjects and a lower glycemic profile in subjects with T2D, though most differences were statistically not significant. Mean Amplitude of Glycemic Excursion (MAGE) was significantly lower after mango ingestion as compared to bread in CGM data in subjects with T2D. Data show limited glycemic impact of tested mango varieties, comparable to or lower than white bread, especially in T2D subjects. The significant reduction in MAGE observed with mango consumption suggests potential benefits for glycemic variability. With portion control in calorie restrictive diets, mango may be suitable for people with T2D. |
| Author | Palavalli, Rajashekar Reddy Misra, Anoop Gupta, Vimal Bhatt, Surya Prakash Ahmad Ansari, Irshad Kehar, Sugandha Pandey, Ravindra M |
| Author_xml | – sequence: 1 givenname: Sugandha orcidid: 0000-0001-9374-5383 surname: Kehar fullname: Kehar, Sugandha organization: National Diabetes, Obesity and Cholesterol Foundation (N-DOC), New Delhi, India – sequence: 2 givenname: Surya Prakash orcidid: 0000-0001-9489-9747 surname: Bhatt fullname: Bhatt, Surya Prakash organization: Department of Medicine, All India Institute of Medical Sciences, New Delhi, India – sequence: 3 givenname: Ravindra M surname: Pandey fullname: Pandey, Ravindra M organization: Former Professor, All India Institute of Medical Sciences, New Delhi, India – sequence: 4 givenname: Irshad surname: Ahmad Ansari fullname: Ahmad Ansari, Irshad organization: Fortis C-DOC Centre for Excellence for Diabetes, Metabolic Disease, and Endocrinology, New Delhi, India – sequence: 5 givenname: Rajashekar Reddy surname: Palavalli fullname: Palavalli, Rajashekar Reddy organization: Pinaca Technology, Chennai, Tamil Nadu, India – sequence: 6 givenname: Vimal surname: Gupta fullname: Gupta, Vimal organization: Fortis C-DOC Centre for Excellence for Diabetes, Metabolic Disease, and Endocrinology, New Delhi, India – sequence: 7 givenname: Anoop orcidid: 0000-0001-5785-5833 surname: Misra fullname: Misra, Anoop email: anoopmisra@gmail.com, anoopmisra@gmail.com, anoopmisra@gmail.com organization: Fortis C-DOC Centre for Excellence for Diabetes, Metabolic Disease, and Endocrinology, New Delhi, India. anoopmisra@gmail.com |
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| SubjectTerms | Adult Aged Blood Glucose - analysis Blood Glucose - metabolism Blood Glucose Self-Monitoring Bread Cross-Over Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diet therapy Diet Female Fruit Glucose Tolerance Test Glycemic Index Humans Male Mangifera Middle Aged Pilot Projects Postprandial Period |
| Title | Glycemic responses of three mango varieties in subjects with and without T2D: a pilot crossover study using OTT and CGM |
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