The evolution of post-translational modifications
Post-translational modifications (PTMs) are chemical modifications that can regulate the activity and function of proteins. From an evolutionary perspective, they also represent a fast mechanism for the generation of phenotypic diversity and divergence. Advances in mass spectrometry have now enabled...
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| Vydané v: | Current opinion in genetics & development Ročník 76; s. 101956 |
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| Hlavný autor: | |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Elsevier Ltd
01.10.2022
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| ISSN: | 0959-437X, 1879-0380, 1879-0380 |
| On-line prístup: | Získať plný text |
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| Shrnutí: | Post-translational modifications (PTMs) are chemical modifications that can regulate the activity and function of proteins. From an evolutionary perspective, they also represent a fast mechanism for the generation of phenotypic diversity and divergence. Advances in mass spectrometry have now enabled the identification of over 600 distinct PTM classes collectively spanning an order of 106 unique sites. However, the chemical detection of PTMs has lagged far behind their functional characterisation, and relatively little is still known about the selective constraints that govern PTM evolution. In particular, the true fraction of PTM sites that are functional — and thus subject to selection — remains an open question. Here, I review advances made in the past two years towards understanding the evolution of PTMs and their associated enzymes. |
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| Bibliografia: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 0959-437X 1879-0380 1879-0380 |
| DOI: | 10.1016/j.gde.2022.101956 |