Release and Activity of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease

Destruction of lung elastin is critical for development of emphysema associated with chronic obstructive pulmonary disease (COPD). Lung macrophages release elastolytic enzymes, including matrix metalloproteinase (MMP)-9, along with tissue inhibitors of MMP (TIMP). We examined the production and acti...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 26; no. 5; pp. 602 - 609
Main Authors:	Russell, Richard E. K, Culpitt, Sarah V, DeMatos, Carmen, Donnelly, Louise, Smith, Michael, Wiggins, John, Barnes, Peter J
Format:	Journal Article
Language:	English
Published:	United States Am Thoracic Soc 01.05.2002
Subjects:	Aged Bronchoalveolar Lavage Fluid - cytology Cell Count Cells, Cultured Culture Media, Conditioned - pharmacology Dexamethasone - pharmacology Dose-Response Relationship, Drug Enzyme Activation - drug effects Female Glucocorticoids - pharmacology Humans Interleukin-1 - pharmacology Lipopolysaccharides - pharmacology Macrophages, Alveolar - cytology Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Male Matrix Metalloproteinase 9 - biosynthesis Middle Aged Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Smoking - metabolism Smoking - pathology Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tobacco Smoke Pollution
ISSN:	1044-1549, 1535-4989
Online Access:	Get full text
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