Antiparkinsonian Activity of Benzenesulfonamide Derivatives, Selective MAO-B Inhibitors

The anti-parkinsonian activity of benzolsulfonamide selective MAO-B inhibitors was evaluated in a model of experimental parkinsonism in white mice (systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP). Six candidate compounds (laboratory codes S6-S8 and S11-S13) were analyz...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 179; no. 3; pp. 312 - 316
Main Authors:	Khokhlov, A. L., Fedorov, V. N., Shetnev, A. A., Korsakov, M. K., Petukhov, S. S., Vdovichenko, V. P., Khokhlova, A. A., Suleimanov, S. Sh
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.07.2025 Springer Nature B.V
Subjects:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Amine oxidase (flavin-containing) Animals Antiparkinson Agents - chemistry Antiparkinson Agents - pharmacology Antiparkinson Agents - therapeutic use Basal ganglia Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system diseases Disease Disease Models, Animal Dopamine Drug dosages Drug therapy Emotional behavior Indans - pharmacology Internal Medicine Laboratory Medicine Male Mice Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - pharmacology Monoamine Oxidase Inhibitors - therapeutic use Movement disorders MPTP Normal distribution Parkinson's disease Pathogenesis Pathology Pharmaceuticals Rasagiline Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology benzenesulfonamide derivative MAO inhibitors Parkinson’s disease experimental parkinsonism
ISSN:	0007-4888, 1573-8221, 1573-8221
Online Access:	Get full text
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