Disrupted static and dynamic Large-scale brain functional network connectivity in the differentiation of myelin oligodendrocyte glycoprotein Antibody-Seropositive from seronegative optic neuritis

Purpose The ability to distinguish myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis (MOG-ON) from seronegative-ON is critical in clinical practice. We investigate potential neural mechanisms and differentiation biomarkers via large-scale functional network connectivity (FNC)...

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Veröffentlicht in:Neuroradiology Jg. 67; H. 8; S. 2107 - 2119
Hauptverfasser: Wang, Wentao, Liu, Xilan, Sha, Yan, Wang, Ximing, Lu, Ping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2025
Springer Nature B.V
Schlagworte:
Adult
Antibodies
Autoantibodies - blood
Biomarkers
Biomarkers - blood
Brain
Brain research
Case-Control Studies
Clinical medicine
Cluster analysis
Diagnosis, Differential
Differential diagnosis
Differentiation
Disease
Dwell time
Eye movements
Female
Functional magnetic resonance imaging
Glycoproteins
Humans
Imaging
Independent component analysis
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Myelin
Myelin-Oligodendrocyte Glycoprotein - immunology
Neural networks
Neuritis
Neuroimaging
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Oligodendrocyte-myelin glycoprotein
Optic nerve
Optic neuritis
Optic Neuritis - blood
Optic Neuritis - diagnostic imaging
Optic Neuritis - immunology
Optic Neuritis - physiopathology
Radiology
Software
Time series
Visual impairment
Myelin oligodendrocyte glycoprotein
Functional network connectivity
Optic neuritis
Independent component analysis
ISSN:0028-3940, 1432-1920, 1432-1920
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Zusammenfassung:Purpose The ability to distinguish myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis (MOG-ON) from seronegative-ON is critical in clinical practice. We investigate potential neural mechanisms and differentiation biomarkers via large-scale functional network connectivity (FNC) using resting-state functional magnetic resonance imaging (RS-fMRI). Methods RS-fMRI-based independent component analysis (ICA) was performed in 79 subjects, including 23 with MOG-ON, 30 with seronegative-ON and 26 healthy controls (HCs). The resting-state networks (RSNs) extracted from the ICA were used to investigate static FNC (sFNC) changes within and between groups. In addition, 5 dynamic FNC (dFNC) states were identified using k-means cluster analysis, and several state-related properties were calculated. Receiver operating characteristic (ROC) curve analysis was also performed to determine its value in differential diagnosis. Results In the sFNC analysis, the patient groups showed decreased intranetwork functional connectivity (FC) within several RSNs compared to the HC group. The MOG-ON group presented significantly altered intranetwork FC in the medial visual network (mVN) and posterior default mode network (pDMN) compared with the seronegative-ON group. Compared with the HCs, the patient groups also presented abnormal internetwork FC between RSNs. In the dFNC analysis, the patient groups presented altered fractional occupancy and dwell times in states 1 and 5 compared with HCs, and the changes in state-related metrics were also distinct between the MOG-ON and seronegative-ON groups. In terms of ROC curve analysis, optimal diagnostic performance was achieved by combining static and dynamic approaches. Conclusions Abnormal large-scale static and dynamic brain functional networks may help to better understand the neural mechanisms of MOG-ON and seronegative-ON and their differentiation.
Bibliographie:ObjectType-Article-1
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ISSN:0028-3940
1432-1920
1432-1920
DOI:10.1007/s00234-025-03643-9