Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis

Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action is via blockade of axonal voltage gated potassium channels, th...

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Vydané v:	Brain (London, England : 1878) Ročník 143; číslo 4; s. 1127
Hlavní autori:	Dietrich, Michael, Koska, Valeria, Hecker, Christina, Göttle, Peter, Hilla, Alexander M, Heskamp, Annemarie, Lepka, Klaudia, Issberner, Andrea, Hallenberger, Angelika, Baksmeier, Christine, Steckel, Julia, Balk, Lisanne, Knier, Benjamin, Korn, Thomas, Havla, Joachim, Martínez-Lapiscina, Elena H, Solà-Valls, Nuria, Manogaran, Praveena, Olbert, Elisabeth D, Schippling, Sven, Cruz-Herranz, Andrés, Yiu, Hao, Button, Julia, Caldito, Natalia Gonzalez, von Gall, Charlotte, Mausberg, Anne K, Stettner, Mark, Zimmermann, Hannah G, Paul, Friedemann, Brandt, Alexander U, Küry, Patrick, Goebels, Norbert, Aktas, Orhan, Berndt, Carsten, Saidha, Shiv, Green, Ari J, Calabresi, Peter A, Fischer, Dietmar, Hartung, Hans-Peter, Albrecht, Philipp
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.04.2020
Predmet:	4-aminopyridine optical coherence tomography multiple sclerosis NFAT experimental optic neuritis
ISSN:	1460-2156, 1460-2156
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