Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae

The ‘silent pandemic’ caused by antimicrobial resistance requires innovative therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most transformative and safe drugs in oncology 1 and autoimmunity 2 , are rarely used for infectious diseases and not yet used for antimicrobia...

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Bibliographic Details
Published in:	Nature (London) Vol. 646; no. 8087; pp. 1204 - 1213
Main Authors:	Roscioli, Emanuele, Zucconi Galli Fonseca, Vittoria, Bosch, Soraya Soledad, Paciello, Ida, Maccari, Giuseppe, Cardinali, Giulia, Batani, Giampiero, Stazzoni, Samuele, Tiseo, Giusy, Giordano, Cesira, Yuwei, Shen, Capoccia, Laura, Cardamone, Dario, Ridelfi, Matteo, Troisi, Marco, Manganaro, Noemi, Mugnaini, Chiara, De Santi, Concetta, Ciabattini, Annalisa, Cerofolini, Linda, Fragai, Marco, Licastro, Danilo, Wyres, Kelly, Dortet, Laurent, Barnini, Simona, Nicolau, David P., Menichetti, Francesco, Falcone, Marco, Abdelraouf, Kamilia, Sala, Claudia, Kabanova, Anna, Rappuoli, Rino
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.10.2025 Nature Publishing Group
Subjects:	14/1 631/250/2499 631/250/255/1318 631/326/421 Animals Anti-Bacterial Agents - pharmacology Antibiotics Antibodies Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens Antimicrobial resistance Bacteremia - microbiology Bacteremia - prevention & control Bacteria Bacterial Capsules - immunology Bactericidal activity Carbapenems Drug resistance Drug Resistance, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - immunology FDA approval Female Flow cytometry Genomes Humanities and Social Sciences Humans Infectious diseases Klebsiella Klebsiella Infections - drug therapy Klebsiella Infections - immunology Klebsiella Infections - microbiology Klebsiella Infections - prevention & control Klebsiella pneumoniae Klebsiella pneumoniae - classification Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - growth & development Klebsiella pneumoniae - immunology Klebsiella pneumoniae - pathogenicity Macrophages Macrophages - immunology Macrophages - microbiology Male Medical innovations Mice Monoclonal antibodies multidisciplinary Nosocomial infections O Antigens - immunology Pathogens Science Science (multidisciplinary) Septicemia Virulence
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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