Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve chemical synthesis. Combining enzymatic reactions into multistep biocatalytic cascades brings additional benefits. Cascades avoid the waste gen...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 366; H. 6470; S. 1255
Hauptverfasser:	Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.12.2019
Schlagworte:	Biocatalysis Biotechnology - methods Deoxyadenosines - chemistry Pharmaceutical Preparations - chemical synthesis Reverse Transcriptase Inhibitors - chemistry Stereoisomerism
ISSN:	1095-9203, 1095-9203
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