Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve chemical synthesis. Combining enzymatic reactions into multistep biocatalytic cascades brings additional benefits. Cascades avoid the waste gen...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 366; číslo 6470; s. 1255
Hlavní autoři:	Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.12.2019
Témata:	Biocatalysis Biotechnology - methods Deoxyadenosines - chemistry Pharmaceutical Preparations - chemical synthesis Reverse Transcriptase Inhibitors - chemistry Stereoisomerism
ISSN:	1095-9203, 1095-9203
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