Algorithmic Issues in Reverse Engineering of Protein and Gene Networks via the Modular Response Analysis Method

:  This paper studies a computational problem motivated by the modular response analysis method for reverse engineering of protein and gene networks. This set‐cover problem is hard to solve exactly for large networks, but efficient approximation algorithms are given and their complexity is analyzed....

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Vydané v:	Annals of the New York Academy of Sciences Ročník 1115; číslo 1; s. 132 - 141
Hlavní autori:	BERMAN, PIOTR, DASGUPTA, BHASKAR, SONTAG, EDUARDO
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Malden, USA Blackwell Publishing Inc 01.12.2007
Predmet:	Algorithms biological networks Biomedical Engineering - methods Computational Biology - methods Computer Simulation Gene Expression - physiology Gene Expression Profiling - methods Gene Expression Regulation - physiology Models, Biological Proteome - metabolism randomized approximation algorithms reverse engineering set multicover Signal Transduction - physiology
ISSN:	0077-8923, 1749-6632, 1930-6547
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