Platelet COX and LOX enzymes orchestrate amyloid-β secretion via RhoA signaling: Implications for neurodegenerative diseases

Arachidonic acid metabolism through cyclooxygenase (COX) and lipoxygenase (LOX) pathways is fundamental to inflammation, vascular homeostasis, and neuronal signaling. Here, we investigated the roles of platelet-expressed COX (PTGS1) and LOX (ALOX12) isoforms in amyloid-β (Aβ) secretion, a process im...

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Veröffentlicht in:	Free radical biology & medicine Jg. 240; S. 641 - 649
Hauptverfasser:	Trostchansky, A., Alarcón, M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.12.2025
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid-β Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism Blood Platelets - enzymology Blood Platelets - metabolism Cerebral Amyloid Angiopathy - genetics Cerebral Amyloid Angiopathy - metabolism Cerebral Amyloid Angiopathy - pathology Cyclooxygenase Cyclooxygenase 1 - genetics Cyclooxygenase 1 - metabolism Humans Lipoxygenase Peptide Fragments - metabolism Platelet Activation Platelets rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Signal Transduction Cyclooxygenase Amyloid-β Lipoxygenase Platelets
ISSN:	0891-5849, 1873-4596, 1873-4596
Online-Zugang:	Volltext
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