IDH1 mutated prostate cancer with psammomatous calcifications: A case report and review of the literature

We report a case of grade group 2, pT 3 N0 Mx prostate acinar adenocarcinoma with intratumoural psammomatous calcifications and IDH1 mutation. This is an emerging molecular subtype of prostate cancer associated with a propensity for higher grade and stage of disease. The index case was of intermedia...

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Vydáno v:Human Pathology Reports Ročník 42; s. 300800
Hlavní autoři: Gaskin, D.A., Reid, A., Depeiza, N., Nebhnani, J., Gaskin, P.S.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier Inc 01.11.2025
Témata:
Afro-Caribbean
Case report
IDH1 mutation
Pathology
Prostate cancer
Prostatic carcinoma
Psammomatous carcinoma
IDH1 mutation
Case report
Psammomatous carcinoma
Prostatic carcinoma
Prostate cancer
Afro-Caribbean
ISSN:2772-736X, 2772-736X
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Shrnutí:We report a case of grade group 2, pT 3 N0 Mx prostate acinar adenocarcinoma with intratumoural psammomatous calcifications and IDH1 mutation. This is an emerging molecular subtype of prostate cancer associated with a propensity for higher grade and stage of disease. The index case was of intermediate grade but had locally advanced stage III disease.
ISSN:2772-736X
2772-736X
DOI:10.1016/j.hpr.2025.300800