Endocrine-disruptor endpoints in the ovary and thyroid of adult female rats exposed to realistic doses of di-(2-ethylhexyl) phthalate

Di-(2-ethylhexyl) phthalate (DEHP) is the world's most widely used polyvinyl chloride (PVC) plasticizer and is used in virtually every category of flexible PVC. In fact, DEHP is extensively used in food cosmetics and medical packaging. It has become a serious problem in recent years. DEHP can b...

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Published in:Journal of water and health Vol. 20; no. 8; pp. 1256 - 1267
Main Authors: Jebara, Amel, Beltifa, Asma, Di Bella, Guissepa, Mabrouk, Lotfi, Ben Mansour, Hedi
Format: Journal Article
Language:English
Published: London IWA Publishing 01.08.2022
Subjects:
Alanine
Alanine transaminase
analysis of biochemical markers
Apoptosis
Aspartate aminotransferase
Cosmetics
Cysts
Damage
dehp
Dioctyl phthalate
Endocrine disruptors
endocrine-disruptor
environmental contamination
Estrogens
Females
Follicles
Folliculogenesis
Food
Food packaging
Foods
Granulosa cells
Hepatocytes
Histopathology
Hormones
in vivo toxicity
Laboratory animals
Oestrogens
Oils & fats
Ovaries
Phthalates
Pollutants
Polyvinyl chloride
Progesterone
Puberty
Reproductive system
Sex hormones
Thyroid
Thyroid gland
Transaminases
Tunisia
ISSN:1477-8920, 1996-7829
Online Access:Get full text
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Summary:Di-(2-ethylhexyl) phthalate (DEHP) is the world's most widely used polyvinyl chloride (PVC) plasticizer and is used in virtually every category of flexible PVC. In fact, DEHP is extensively used in food cosmetics and medical packaging. It has become a serious problem in recent years. DEHP can be absorbed into the human body through the air, food, water, and skin. The current study involved intraperitoneal injection of DEHP dissolved in corn oil once daily for 21 consecutive days to investigate the effects of DEHP on the thyroid and the reproductive system in female rats. Results show that ovarian hormones (progesterone and estrogen) decreased significantly in the rats treated with DEHP compared to control. This result is supported by the alteration of folliculogenesis, the decrease of the follicles viability, and the apoptosis of the granulosa cells observed on histological sections of ovary and thyroid in female rats exposed to low doses of DEHP. Histopathological study revealed that DEHP could damage thyroid tissue and disrupt these functions. We also observed cellular damage, particularly in the liver cells, and a significant increase in biochemical parameters such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) compared to the control group.
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ISSN:1477-8920
1996-7829
DOI:10.2166/wh.2022.140