Biotechnological solutions for critical mineral recovery from unconventional feedstocks

Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature’s ability to extract and differentiate metal ions in biotechnologies that could become the n...

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Veröffentlicht in:Current opinion in biotechnology Jg. 95; S. 103336
Hauptverfasser: Zurier, Hannah S, Banta, Scott, Park, Dan M, Reed, David W, Werner, Allison Z
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.10.2025
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ISSN:0958-1669, 1879-0429, 1879-0429
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Abstract Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature’s ability to extract and differentiate metal ions in biotechnologies that could become the next generation of mining and refining. We describe bulk and trace processes and then discuss the advances and opportunities of two key bioprocesses: microbially mediated solubilization of metal ions from solid matrices (termed ‘bioleaching’) and bio-based separation of solubilized ions via selective adsorption to proteins. Both biotechnologies have advantages such as reduced energy input for leaching low-grade feedstocks and reduced organic solvent demand for separating ions with similar physiochemical properties but require more development for industrial scale recovery from unconventional feedstocks. Innovation in biological science and engineering may bring timely solutions to key challenges toward recovering critical minerals from unconventional feedstocks. [Display omitted] •Microbes can catalyze reactions or produce chelators that solubilize metal ions (‘bioleaching’).•Proteins can selectively bind to metal ions, enabling aqueous metal separations.•Biotechnology advances could overcome key challenges towards critical mineral recovery.
AbstractList Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature's ability to extract and differentiate metal ions in biotechnologies that could become the next generation of mining and refining. We describe bulk and trace processes and then discuss the advances and opportunities of two key bioprocesses: microbially mediated solubilization of metal ions from solid matrices (termed 'bioleaching') and bio-based separation of solubilized ions via selective adsorption to proteins. Both biotechnologies have advantages such as reduced energy input for leaching low-grade feedstocks and reduced organic solvent demand for separating ions with similar physiochemical properties but require more development for industrial scale recovery from unconventional feedstocks. Innovation in biological science and engineering may bring timely solutions to key challenges toward recovering critical minerals from unconventional feedstocks.Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature's ability to extract and differentiate metal ions in biotechnologies that could become the next generation of mining and refining. We describe bulk and trace processes and then discuss the advances and opportunities of two key bioprocesses: microbially mediated solubilization of metal ions from solid matrices (termed 'bioleaching') and bio-based separation of solubilized ions via selective adsorption to proteins. Both biotechnologies have advantages such as reduced energy input for leaching low-grade feedstocks and reduced organic solvent demand for separating ions with similar physiochemical properties but require more development for industrial scale recovery from unconventional feedstocks. Innovation in biological science and engineering may bring timely solutions to key challenges toward recovering critical minerals from unconventional feedstocks.
Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature’s ability to extract and differentiate metal ions in biotechnologies that could become the next generation of mining and refining. We describe bulk and trace processes and then discuss the advances and opportunities of two key bioprocesses: microbially mediated solubilization of metal ions from solid matrices (termed ‘bioleaching’) and bio-based separation of solubilized ions via selective adsorption to proteins. Both biotechnologies have advantages such as reduced energy input for leaching low-grade feedstocks and reduced organic solvent demand for separating ions with similar physiochemical properties but require more development for industrial scale recovery from unconventional feedstocks. Innovation in biological science and engineering may bring timely solutions to key challenges toward recovering critical minerals from unconventional feedstocks. [Display omitted] •Microbes can catalyze reactions or produce chelators that solubilize metal ions (‘bioleaching’).•Proteins can selectively bind to metal ions, enabling aqueous metal separations.•Biotechnology advances could overcome key challenges towards critical mineral recovery.
Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature's ability to extract and differentiate metal ions in biotechnologies that could become the next generation of mining and refining. We describe bulk and trace processes and then discuss the advances and opportunities of two key bioprocesses: microbially mediated solubilization of metal ions from solid matrices (termed 'bioleaching') and bio-based separation of solubilized ions via selective adsorption to proteins. Both biotechnologies have advantages such as reduced energy input for leaching low-grade feedstocks and reduced organic solvent demand for separating ions with similar physiochemical properties but require more development for industrial scale recovery from unconventional feedstocks. Innovation in biological science and engineering may bring timely solutions to key challenges toward recovering critical minerals from unconventional feedstocks.
ArticleNumber 103336
Author Zurier, Hannah S
Werner, Allison Z
Reed, David W
Banta, Scott
Park, Dan M
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  givenname: Hannah S
  orcidid: 0000-0002-6576-148X
  surname: Zurier
  fullname: Zurier, Hannah S
  organization: Department of Chemical Engineering, Columbia University, New York, NY, USA
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  givenname: Scott
  orcidid: 0000-0001-7885-0150
  surname: Banta
  fullname: Banta, Scott
  email: sb2373@columbia.edu
  organization: Department of Chemical Engineering, Columbia University, New York, NY, USA
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  givenname: Dan M
  surname: Park
  fullname: Park, Dan M
  email: park36@llnl.gov
  organization: Physical and Life Sciences, Lawrence Livermore National Lab, Livermore, CA, USA
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  givenname: David W
  orcidid: 0000-0003-4877-776X
  surname: Reed
  fullname: Reed, David W
  email: david.reed@inl.gov
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  givenname: Allison Z
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  surname: Werner
  fullname: Werner, Allison Z
  email: allison.werner@nrel.gov
  organization: Renewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA
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SubjectTerms Biotechnology - methods
Metals - chemistry
Metals - isolation & purification
Minerals - chemistry
Minerals - isolation & purification
Minerals - metabolism
Title Biotechnological solutions for critical mineral recovery from unconventional feedstocks
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