Properties governing small-molecule partitioning into biomolecular condensates

Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now reveals that physicochemical features, not specific stereochemistry, influence whether small molecules are enriched within or excluded from a...

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Bibliographic Details
Published in:Nature chemistry Vol. 16; no. 11; pp. 1743 - 1745
Main Authors: Chandra, Bappaditya, Tripathi, Swarnendu, Kriwacki, Richard
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.11.2024
Nature Publishing Group
Subjects:
631/92/613
639/638/92/507
Analytical Chemistry
Biochemistry
Biological activity
Biological properties
Biopolymers
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Condensates
Drug development
Inorganic Chemistry
Machine learning
Mass spectrometry
Metabolites
News & Views
news-and-views
Organic Chemistry
Physical Chemistry
R&D
Research & development
Scientific imaging
Stereochemistry
ISSN:1755-4330, 1755-4349, 1755-4349
Online Access:Get full text
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Summary:Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now reveals that physicochemical features, not specific stereochemistry, influence whether small molecules are enriched within or excluded from a diverse panel of condensates.
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ISSN:1755-4330
1755-4349
1755-4349
DOI:10.1038/s41557-024-01655-1