Pioglitazone improves learning and memory in a rat model of cholinergic dysfunction induced by scopolamine, the roles of oxidative stress and neuroinflammation

Alzheimer's disease (AD) is a major neurodegenerative disorder characterized by progressive cognitive decline. Among various experimental models, scopolamine-induced amnesia is widely used to mimic memory dysfunction. Pioglitazone (PG), a thiazolidinedione derivative, has recently demonstrated...

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Bibliographic Details
Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 398; no. 8; pp. 10221 - 10237
Main Authors:	Rajabian, Arezoo, Kioumarsi Darbandi, Zahra, Aliyari, Mahdieh, Saberi, Rasul, Amirahmadi, Sabiheh, Amini, Hamideh, Salmani, Hossein, Youseflee, Pouya, Hosseini, Mahmoud
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2025 Springer Nature B.V
Subjects:	Acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer's disease Amnesia Animal cognition Animal models Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Brain Cognitive ability Cognitive Dysfunction - chemically induced Cognitive Dysfunction - drug therapy Dementia Disease Models, Animal Gene expression Hippocampus Hippocampus - drug effects Hippocampus - metabolism IL-1β Inflammation Interleukin 6 Laboratory animals Learning Male Maze Learning - drug effects Memory Memory - drug effects Memory Disorders - chemically induced Memory Disorders - drug therapy Neurodegeneration Neurodegenerative diseases Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - metabolism Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Pioglitazone Pioglitazone - pharmacology Pioglitazone - therapeutic use Rats Rats, Wistar Scopolamine Superoxide dismutase Tumor necrosis factor-TNF Tumor necrosis factor-α Oxidative stress Neuroinflammation Scopolamine Pioglitazone Cognitive impairment
ISSN:	0028-1298, 1432-1912, 1432-1912
Online Access:	Get full text
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