Combined Novel Microfocused Ultrasound and Microneedle Fractional Radiofrequency System for Multilayered Facial Rejuvenation: A Prospective, Randomized, and Split‐Face Study

ABSTRACT Background With the aging population, the demand for skin anti‐aging treatments has been steadily rising, prompting the development of advanced non‐invasive therapies. Aims To evaluate the efficacy and safety of microfocused ultrasound (MFU) combined with microneedle fractional radiofrequen...

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Veröffentlicht in:Journal of cosmetic dermatology Jg. 24; H. 10; S. e70455 - n/a
Hauptverfasser: Wang, Ruiyao, Peng, Guangling, Chen, Yangmei, Shao, Xinyi, Liu, Lin, Chen, Tingqiao, Shi, Mengcen, Zhong, Judan, Ou, Yi, Chen, Jin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.10.2025
Schlagworte:
Adult
Aged
clinical research
Combined Modality Therapy - adverse effects
Combined Modality Therapy - instrumentation
Combined Modality Therapy - methods
Cosmetic Techniques - adverse effects
Cosmetic Techniques - instrumentation
Face
facial rejuvenation
Female
Humans
Male
microfocused ultrasound
microneedle fractional radiofrequency
Middle Aged
Needles
Patient Satisfaction
Prospective Studies
Radiofrequency Therapy - adverse effects
Radiofrequency Therapy - instrumentation
Rejuvenation
Skin - diagnostic imaging
Skin - radiation effects
Skin Aging - radiation effects
Subcutaneous Fat - diagnostic imaging
Treatment Outcome
Ultrasonic Therapy - adverse effects
Ultrasonic Therapy - instrumentation
Ultrasonic Therapy - methods
Ultrasonography
microneedle fractional radiofrequency
facial rejuvenation
microfocused ultrasound
clinical research
ISSN:1473-2130, 1473-2165, 1473-2165
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Zusammenfassung:ABSTRACT Background With the aging population, the demand for skin anti‐aging treatments has been steadily rising, prompting the development of advanced non‐invasive therapies. Aims To evaluate the efficacy and safety of microfocused ultrasound (MFU) combined with microneedle fractional radiofrequency (MFR) for facial rejuvenation. Methods This study involved 26 patients experiencing facial laxity. Each patient received one full‐face MFU treatment and one MFR treatment on one side of the face, which was randomly assigned. All treatments were performed on the same day. Facial photoaging parameters were assessed using VISIA, skin fat thickness changes were measured via ultrasound, and subjective evaluations were recorded at Months 0, 1, and 3. Side effects were recorded during treatments and each follow‐up visit. Results The VISIA analysis demonstrated notable enhancements in skin texture, wrinkles, pores, spots, and red areas on the combined treatment side. Ultrasound examinations revealed a significant reduction in subcutaneous fat thickness, particularly at the masseter and the middle of the cheek on the combined side. The study showed improvements in the Global Aesthetic Improvement Scale (GAIS) and Wrinkle Severity Rating Scale (WSRS) scores, with the combined treatment side outperforming the control side at the 3 month mark. Over 90% of participants expressed satisfaction with the treatment outcomes. Mild side effects, such as erythema, purpura, and edema, were observed but resolved without special interventions. Conclusions The combination of MFU and MFR for facial rejuvenation is both safe and effective. The combined treatment demonstrates superior enhancement in skin tightening, depigmentation, and pore refinement within a single therapeutic session.
Bibliographie:Funding
Ruiyao Wang, Guangling Peng, and Yangmei Chen contributed equally to this work.
The present study was supported by the Program for Youth Innovation in Future Medicine of Chongqing Medical University, the Chongqing talent plan project (cstc2024ycjhbgzxm0177), and the Chongqing Science and Technology Commission (2023NSCQ‐MSX0321).
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ISSN:1473-2130
1473-2165
1473-2165
DOI:10.1111/jocd.70455