Pruritus may precede abnormal liver function tests in pregnant women with obstetric cholestasis: a longitudinal analysis

Obstetric cholestasis is a liver disorder unique to pregnancy, which typically presents with pruritus. However, pruritus is common in pregnancy and the diagnosis of obstetric cholestasis is confirmed by finding abnormal liver function. We report 10 cases in which pruritus occurred before any abnorma...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology Vol. 108; no. 11; pp. 1190 - 1192
Main Authors: Kenyon, Anna P., Piercy, C. Nelson, Girling, J., Williamson, C., Tribe, R.M., Shennan, A.H.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Science Ltd 01.11.2001
Blackwell
Subjects:
Adult
Biological and medical sciences
Cholestasis - complications
Cholestasis - physiopathology
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Humans
Liver Function Tests
Longitudinal Studies
Medical sciences
Pregnancy
Pregnancy Complications - physiopathology
Pregnancy. Fetus. Placenta
Prospective Studies
Pruritus - etiology
Human
Skin disease
Pregnancy disorders
Pruritus
Biliary tract disease
Case study
Pregnancy
Liver function
Cholostasis
Digestive diseases
Female
Skin
Diagnosis
Inaugural sign
ISSN:1470-0328, 1471-0528
Online Access:Get full text
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Summary:Obstetric cholestasis is a liver disorder unique to pregnancy, which typically presents with pruritus. However, pruritus is common in pregnancy and the diagnosis of obstetric cholestasis is confirmed by finding abnormal liver function. We report 10 cases in which pruritus occurred before any abnormality in liver function tests (including total serum bile acids) and discuss the implications of this for clinical practice.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2003.00281.x